Analytical Data
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基因名
NRK1
- Application
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别名
NMRK1;C9orf95;NRK1;Nicotinamide riboside kinase 1
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种属
Human
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表达系统
E. coli
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标签
His tag N-Terminus
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
Q9NWW6
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表达区间
1-199aa
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氨基酸序列
MGSSHHHHHH SSGLVPRGSH MGSMKTFIIG ISGVTNSGKT TLAKNLQKHL PNCSVISQDD FFKPESEIET DKNGFLQYDV LEALNMEKMM SAISCWMESA RHSVVSTDQE SAEEIPILII EGFLLFNYKP LDTIWNRSYF LTIPYEECKR RRSTRVYQPP DSPGYFDGHV WPMYLKYRQE MQDITWEVVY LDGTKSEEDL FLQVYEDLIQ ELAKQKCLQV TA
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分子量
26 kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
NRK1 (Nicotinic acid riboside kinase 1) is an enzyme that plays a crucial role in the NAD+ (Nicotinamide adenine dinucleotide) biosynthesis pathway, catalyzing the phosphorylation of nicotinamide riboside (NR) to generate NAD+. NAD+ is vital for various cellular processes, including energy metabolism, DNA repair, and cellular signaling. Recent research has highlighted the importance of NRK1 in regulating cellular NAD+ levels, suggesting its potential implications in aging, metabolism, and diseases such as cancer and neurodegenerative disorders. Studies have shown that manipulating NRK1 activity can influence cellular NAD+ pools, thereby impacting key metabolic pathways and stress responses. Moreover, the development of NRK1 recombinant proteins has become critical for investigating its enzymatic properties and understanding its regulatory mechanisms. By producing and characterizing NRK1 in vitro, researchers aim to explore its functional roles, elucidate its structure-function relationships, and evaluate its potential as a therapeutic target. Understanding the intricacies of NRK1 function and its impact on NAD+ homeostasis may offer new avenues for therapeutic interventions in age-related conditions and metabolic diseases, highlighting the significance of this enzyme in health and disease.
