Analytical Data
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Gene name
LSG1
- Application
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Alternative Names
LSG1; Large subunit GTPase 1 homolog; hLsg1; EC 3.6.1.-
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Species
Human
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Source
E. coli
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Tag
GST-tag at N-terminal
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
Q9H089
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Expression Region
1-658aa
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AA Sequence
MGRRRAPAGGSLGRALMRHQTQRSRSHRHTDSWLHTSELNDGYDWGRLNLQSVTEQSSLDDFLATAELAGTEFVAEKLNIKFVPAEARTGLLSFEESQRIKKLHEENKQFLCIPRRPNWNQNTTPEELKQAEKDNFLEWRRQLVRLEEEQKLILTPFERNLDFWRQLWRVIERSDIVVQIVDARNPLLFRCEDLECYVKEMDANKENVILINKADLLTAEQRSAWAMYFEKEDVKVIFWSALAGAIPLNGDSEEEANRDDSQSNTTEFGHSSFDQAEISHSESEHLPARDSPSLSENPTTDEDDSEYEDCPEEEEDDWQTCSEEDGPKEEDCSQDWKESSTADSEARSRKTPQKRQIHNFSHLVSKQELLELFKELHTGRKVKDGQLTVGLVGYPNVGKSSTINTIMGNKKVSVSATPGHTKHFQTLYVEPGLCLCDCPGLVMPSFVSTKAEMTCSGILPIDQMRDHVPPVSLVCQNIPRHVLEATYGINIITPREDEDPHRPPTSEELLTAYGYMRGFMTAHGQPDQPRSARYILKDYVSGKLLYCHPPPGRDPVTFQHQHQRLLENKMNSDEIKMQLGRNKKAKQIENIVDKTFFHQENVRALTKGVQAVMGYKPGSGVVTASTASSENGAGKPWKKHGNRNKKEKSRRLYKHLDM
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Molecular Weight
98.78 kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
The LSG1 protein, a member of the GTPase family, plays a crucial role in the process of protein synthesis and ribosome biogenesis in eukaryotic cells. It is highly conserved across various species, emphasizing its fundamental importance in cellular processes. Research into LSG1 has gained momentum due to its involvement in the regulation of translation and the potential links to various diseases, including cancer. Understanding the mechanisms by which LSG1 functions can provide insights into how cells control protein synthesis, responding to environmental changes and stressors. The study of this protein is particularly relevant in the context of developing therapeutic strategies, as dysregulation of translation is a hallmark of many diseases. Recent advances in molecular biology techniques have enabled scientists to explore the structure and function of LSG1 in greater detail, revealing its interactions with other cellular components and its role in the assembly of the ribosomal machinery. Investigating the effects of recombinant LSG1 protein in vitro and in vivo can help elucidate its function and importance. Furthermore, the potential use of LSG1 as a biomarker or target for drug development represents an exciting area of research that could have significant implications for medical science. Overall, the study of LSG1 and its recombinant forms is vital for understanding the intricate network of molecular interactions that govern cellular function and highlights the protein's significance in both basic research and clinical applications.
