Analytical Data
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Gene name
EphA5
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简介
EPHA5 is a member of the erythropoietin-producing human liver cancer receptor (Eph receptor) that regulates embryogenesis by fine-tuning cell adhesion, localization, and migration, particularly in the nervous system. EPHA5 enhances the invasion and migration of esophageal squamous cell carcinoma through epithelial-mesenchymal transformation by activating the Wnt/β-catenin pathway. EPHA5 Protein, Cynomolgus (HEK293, His) is the recombinant cynomolgus-derived EPHA5 protein, expressed by HEK293 , with C-His labeled tag.
- Application
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Alternative Names
EHK-1; EK7; BSK; EHK1; HEK7; TYRO4; EphA5; Rek7; TYRO4HEK7CEK7
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Species
Cynomolgus
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Source
HEK293
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Tag
C-8*His
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
A0A2K5W6J6
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Expression Region
P25-Q572
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Protein Length
Partial
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Molecular Weight
70-75kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
EphA5 is a member of the Eph receptor tyrosine kinase family, which plays critical roles in various biological processes, including cell adhesion, migration, and neuronal development. The Eph receptors interact with their ligands, known as Ephrin-A and Ephrin-B, to mediate bidirectional signaling that is pivotal for tissue remodeling and the establishment of cellular boundaries. Research on EphA5 has gained significant interest due to its involvement in cancer progression and metastasis, where altered expression or activity can influence tumor growth and the metastatic potential of cancer cells. Additionally, EphA5 has been implicated in neurological disorders, making it a potential therapeutic target. The generation of recombinant EphA5 proteins has enabled researchers to elucidate its signaling mechanisms, study its role in various pathophysiological contexts, and explore its potential as a biomarker or target for drug development. As such, the study of EphA5 recombinant proteins is essential for advancing our understanding of its functional characteristics and developing strategies for intervention in diseases associated with aberrant EphA5 activity.
