Analytical Data
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Gene name
ACKR3
- Application
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Alternative Names
C-X-C chemokine receptor type 7 Short name: CXC-R7 Short name: CXCR-7 Chemokine orphan receptor 1 G-protein coupled receptor 159 G-protein coupled receptor RDC1 homolog Short name: RDC-1
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Species
Human
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Source
E. coli
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Tag
N- His-SUMO
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
P25106
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Expression Region
1-362aa
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Protein Length
Partial
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Molecular Weight
57.5 kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
ACKR3, also known as atypical chemokine receptor 3, is a member of the chemokine receptor family that has garnered significant interest in recent years due to its unique role in cellular signaling and disease pathology. Unlike conventional chemokine receptors, ACKR3 primarily functions as a scavenger receptor, sequestering chemokines and preventing them from activating their canonical receptors. This activity plays a crucial role in regulating immune responses and has implications in various diseases, including cancer, cardiovascular disorders, and inflammation. Emerging research has highlighted ACKR3's involvement in promoting tumor progression and metastasis, particularly in certain cancers like breast and pancreatic cancer, where its expression correlates with poor prognosis. The receptor's dual role in both promoting cell survival and modulating immune responses makes it an attractive target for therapeutic interventions. Therefore, the study of recombinant ACKR3 protein aims to elucidate its structural characteristics, binding affinities with various chemokines, and downstream signaling pathways. By generating recombinant ACKR3 proteins, researchers can investigate these aspects in detail, which may contribute to the development of novel therapeutic strategies targeting ACKR3 in disease settings. Understanding the molecular mechanisms governing ACKR3's functions could lead to significant advancements in targeted therapies and improve patient outcomes in diseases where this receptor is implicated.
