Analytical Data
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Gene name
PVRL1
- Application
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Alternative Names
NECTIN1;HVEC;PRR1;PVRL1;Nectin-1
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Species
Human
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Source
E. coli
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Tag
His tag N-Terminus
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
Q15223
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Expression Region
31-355aa
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AA Sequence
QVVQVNDSMY GFIGTDVVLH CSFANPLPSV KITQVTWQKS TNGSKQNVAI YNPSMGVSVL APYRERVEFL RPSFTDGTIR LSRLELEDEG VYICEFATFP TGNRESQLNL TVMAKPTNWI EGTQAVLRAK KGQDDKVLVA TCTSANGKPP SVVSWETRLK GEAEYQEIRN PNGTVTVISR YRLVPSREAH QQSLACIVNY HMDRFKESLT LNVQYEPEVT IEGFDGNWYL QRMDVKLTCK ADANPPATEY HWTTLNGSLP KGVEAQNRTL FFKGPINYSL AGTYICEATN PIGTRSGQVE VNITEFPYTP SPPEHGRRAG PVPTA
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
PVRL1, also known as poliovirus receptor-related 1, is a member of the immunoglobulin superfamily and plays a crucial role in various biological processes, including cell adhesion and immune response modulation. This protein is predominantly expressed in epithelial cells and has been implicated in several pathophysiological conditions, such as cancer and viral infections, where it may facilitate tumor growth and the entry of pathogens into host cells. Research on PVRL1 has gained momentum due to its potential as a therapeutic target; for instance, understanding its interactions with viral agents could lead to novel antiviral strategies. Additionally, PVRL1's involvement in cell signaling pathways highlights its importance in tissue homeostasis and development. Advances in recombinant protein technology have enabled the production of PVRL1 in various expression systems, facilitating detailed structural and functional analyses. Studies focus on elucidating its molecular mechanisms, including ligand binding and signaling pathways, to better comprehend its roles in health and disease. The ongoing investigation of PVRL1 and its recombinant forms not only enhances our understanding of fundamental biological processes but also opens avenues for developing innovative therapeutic interventions targeting related disorders.
