Analytical Data
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基因名
NECAP2
- Application
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别名
GGA3;KIAA0154;ADP-ribosylation factor-binding Protein GGA3
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种属
Human
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表达系统
E. coli
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标签
His tag N-Terminus
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
Q9NVZ3
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表达区间
1-263aa
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氨基酸序列
MGSSHHHHHHSSGLVPRGSHMEESGYESVLCVKPDVHVYRIPPRATNRGY RAAEWQLDQPSWSGRLRITAKGQMAYIKLEDRTSGELFAQAPVDQFPGTA VESVTDSSRYFVIRIEDGNGRRAFIGIGFGDRGDAFDFNVALQDHFKWVK QQCEFAKQAQNPDQGPKLDLGFKEGQTIKLNIANMKKKEGAAGNPRVRPA STGGLSLLPPPPGGKTSTLIPPPGEQLAVGGSLVQPAVAPSSGGAPVPWP QPNPATADIWGDFTKSTGSTSSQTQPGTGWVQF
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分子量
31 kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
The NECAP2 protein, or Neutralizing E-Cadherin Associated Protein 2, has garnered significant attention in recent research due to its crucial role in cellular adhesion and signaling processes. E-Cadherin, a key component of adherens junctions, is essential for maintaining epithelial tissue integrity, and its dysfunction is implicated in various pathologies, including cancer metastasis. NECAP2 interacts with E-Cadherin, influencing cell-cell adhesion and potentially modulating the invasiveness of cancer cells. The study of NECAP2, particularly in the context of its recombinant protein form, is pivotal for understanding its biochemical properties and functional mechanisms in cellular adhesion pathways. This research can lead to novel therapeutic strategies targeting NECAP2 or its pathways to inhibit tumor progression. Furthermore, characterizing the recombinant NECAP2 protein can provide insights into its potential as a biomarker for certain cancers, enhancing diagnostic and prognostic capabilities. Therefore, exploring the molecular dynamics and interactions of NECAP2 presents a promising avenue for advancing cancer biology and developing innovative treatment modalities.
