Analytical Data
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Gene name
SMPD2
- Application
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Alternative Names
SMPD2；Sphingomyelin phosphodiesterase 2
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Species
Human
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Source
E. coli
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Tag
His tag N-Terminus
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
O60906
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Expression Region
1-423aa
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AA Sequence
MKPNFSLRLRIFNLNCWGIPYLSKHRADRMRRLGDFLNQESFDLALLEEVWSEQDFQYLRQKLSPTYPAAHHFRSGIIGSGLCVFSKHPIQELTQHIYTLNGYPYMIHHGDWFSGKAVGLLVLHLSGMVLNAYVTHLHAEYNRQKDIYLAHRVAQAWELAQFIHHTSKKADVVLLCGDLNMHPEDLGCCLLKEWTGLHDAYLETRDFKGSEEGNTMVPKNCYVSQQELKPFPFGVRIDYVLYKAVSGFYISCKSFETTTGFDPHRGTPLSDHEALMATLFVRHSPPQQNPSSTHGPAERSPLMCVLKEAWTELGLGMAQARWWATFASYVIGLGLLLLALLCVLAAGGGAGEAAILLWTPSVGLVLWAGAFYLFHVQEVNGLYRAQAELQHVLGRAREAQDLGPEPQPALLLGQQEGDRTKEQ
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Molecular Weight
49.1 kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
SMPD2 (sphingomyelin phosphodiesterase 2) is an important enzyme involved in sphingolipid metabolism, particularly in the hydrolysis of sphingomyelin to generate ceramide and phosphocholine. This enzyme plays a significant role in various cellular processes, including apoptosis, cell signaling, and membrane dynamics. Dysregulation of SMPD2 has been implicated in several diseases, such as cancer and neurodegenerative disorders, highlighting its potential as a therapeutic target. Recent studies have focused on the structural and functional characterization of SMPD2 in order to better understand its mechanisms of action and regulatory pathways. Recombinant SMPD2 proteins have been produced to facilitate biochemical assays and functional studies, allowing researchers to investigate the enzyme’s kinetic properties, substrate specificity, and interaction with other cellular components. These insights could pave the way for the development of SMPD2 inhibitors or modulators as novel therapeutic agents. Understanding the biological role of SMPD2 and its involvement in disease mechanisms could lead to new strategies for diagnosis and treatment, making SMPD2 an attractive candidate for further research in the context of drug discovery and disease intervention.
