Analytical Data
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Gene name
KCNJ16
- Application
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Alternative Names
KCNJ16；Inward rectifier potassium channel 16
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Species
Human
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Source
E. coli
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Tag
His tag N-Terminus
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
Q9NPI9
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Expression Region
1-418aa
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AA Sequence
MSYYGSSYHIINADAKYPGYPPEHIIAEKRRARRRLLHKDGSCNVYFKHIFGEWGSYVVDIFTTLVDTKWRHMFVIFSLSYILSWLIFGSVFWLIAFHHGDLLNDPDITPCVDNVHSFTGAFLFSLETQTTIGYGYRCVTEECSVAVLMVILQSILSCIINTFIIGAALAKMATARKRAQTIRFSYFALIGMRDGKLCLMWRIGDFRPNHVVEGTVRAQLLRYTEDSEGRMTMAFKDLKLVNDQIILVTPVTIVHEIDHESPLYALDRKAVAKDNFEILVTFIYTGDSTGTSHQSRSSYVPREILWGHRFNDVLEVKRKYYKVNCLQFEGSVEVYAPFCSAKQLDWKDQQLHIEKAPPVRESCTSDTKARRRSFSAVAIVSSCENPEETTTSATHEYRETPYQKALLTLNRISVESQM
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Molecular Weight
1-418aa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
Related Products
Protein Description
KCNJ16, a member of the potassium ion channel family, encodes an inwardly rectifying potassium channel predominantly expressed in various tissues including the kidney and pancreas. This protein plays a crucial role in maintaining cellular excitability and regulating various physiological processes such as insulin secretion and renal function. Dysregulation of KCNJ16 has been linked to certain genetic disorders, metabolic conditions, and abnormalities in renal health, highlighting its significance in human physiology. Recent studies have focused on characterizing the functional properties of KCNJ16, including its conductance and gating mechanisms, to better understand its physiological roles and potential implications in disease. The production of recombinant KCNJ16 protein enables detailed investigations into its structure and function, paving the way for potential therapeutic interventions targeting channel dysfunction. Understanding KCNJ16 at a molecular level could provide insights into its contribution to potassium homeostasis and its impact on related pathophysiological conditions, making it a valuable target for future research in both basic and clinical science.
