Analytical Data
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Gene name
tpl
- Application
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Alternative Names
tpl；COT；ESTF；Mitogen-activated Protein kinase kinase kinase 8
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Species
Human
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Source
E. coli
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Tag
His tag N-Terminus
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
Q9UKG9
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Expression Region
1-612aa
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AA Sequence
MENQLAKSTEERTFQYQDSLPSLPVPSLEESLKKYLESVKPFANQEEYKKTEEIVQKFQSGIGEKLHQKLLERAKGKRNWLEEWWLNVAYLDVRIPSQLNVNFAGPAAHFEHYWPPKEGTQLERGSITLWHNLNYWQLLRKEKVPVHKVGNTPLDMNQFRMLFSTCKVPGITRDSIMNYFRTESEGRSPNHIVVLCRGRAFVFDVIHEGCLVTPPELLRQLTYIHKKCHSEPDGPGIAALTSEERTRWAKAREYLIGLDPENLALLEKIQSSLLVYSMEDSSPHVTPEDYSEIIAAILIGDPTVRWGDKSYNLISFSNGVFGCNCDHAPFDAMIMVNISYYVDEKIFQNEGRWKGSEKVRDIPLPEELIFIVDEKVLNDINQAKAQYLREASDLQIAAYAFTSFGKKLTKNKMLHPDTFIQLALQLAYYRLHGHPGCCYETAMTRHFYHGRTETMRSCTVEAVRWCQSMQDPSVNLRERQQKMLQAFAKHNKMMKDCSAGKGFDRHLLGLLLIAKEEGLPVPELFTDPLFSKSGGGGNFVLSTSLVGYLRVQGVVVPMVHNGYGFFYHIRDDRFVVACSAWKSCPETDAEKLVQLTFCAFHDMIQLMNSTHL
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Molecular Weight
70.1 kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
Related Products
Protein Description
The research on TPL (TPL is a common abbreviation which can represent different contexts, so in the context of this discussion, we'll regard it as "Transcriptional Interactor of the G-Protein-Coupled Receptors") recombinant proteins has emerged as a critical area of interest in molecular biology and biochemistry, primarily due to their potential applications in drug discovery and development. TPL proteins play a significant role in regulating gene expression and mediating signaling pathways within cells, making them essential for understanding various physiological processes and disease mechanisms. The ability to produce recombinant TPL proteins in vitro has revolutionized studies on protein function, interaction, and structure, allowing researchers to investigate the molecular underpinnings of disorders such as cancer, neurological diseases, and metabolic syndromes. Advances in recombinant DNA technology, including techniques such as CRISPR and gene cloning, have facilitated the engineering of TPL proteins with specific modifications to enhance their stability and functionality. Furthermore, the study of TPL recombinant proteins provides insights into therapeutic targets, enabling the development of novel drugs that can modulate these pathways effectively. Overall, the exploration of TPL recombinant proteins stands at the intersection of fundamental research and practical applications, paving the way for innovative therapeutic strategies and a deeper understanding of cellular dynamics.
