Analytical Data
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Gene name
LDLRAD3
- Application
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Alternative Names
LDLRAD3; LRAD3; Low-density lipoprotein receptor class A domain-containing protein 3; LDLR class A domain-containing protein 3
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Species
Human
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Source
E. coli
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Tag
GST-tag at N-terminal
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
Q86YD5
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Expression Region
1-345aa
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AA Sequence
MWLLGPLCLLLSSAAESQLLPGNNFTNECNIPGNFMCSNGRCIPGAWQCDGLPDCFDKSDEKECPKAKSKCGPTFFPCASGIHCIIGRFRCNGFEDCPDGSDEENCTANPLLCSTARYHCKNGLCIDKSFICDGQNNCQDNSDEESCESSQEPGSGQVFVTSENQLVYYPSITYAIIGSSVIFVLVVALLALVLHHQRKRNNLMTLPVHRLQHPVLLSRLVVLDHPHHCNVTYNVNNGIQYVASQAEQNASEVGSPPSYSEALLDQRPAWYDLPPPPYSSDTESLNQADLPPYRSRSGSANSASSQAASSLLSVEDTSHSPGQPGPQEGTAEPRDSEPSQGTEEV
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Molecular Weight
63.8 kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
LDLRAD3 (Low-Density Lipoprotein Receptor Adaptor Protein 3) is a protein involved in lipid metabolism and cellular cholesterol regulation. It is part of a larger family of proteins that modulate the function of low-density lipoprotein receptors, which play a crucial role in the uptake of cholesterol and lipoproteins by cells. Dysregulation of cholesterol homeostasis is closely linked to various metabolic disorders, including cardiovascular diseases and obesity. Research into the structure and function of LDLRAD3 has gained importance due to its potential role in influencing lipid levels and its implications in health. Recent studies aimed at understanding how LDLRAD3 interacts with other cellular components highlight its significance in the endosomal recycling of LDL receptors and its impact on cholesterol absorption and metabolism. By exploring the mechanisms that govern LDLRAD3 activity, researchers hope to identify new therapeutic targets for managing cholesterol-related diseases. The development of recombinant LDLRAD3 protein is critical for advancing these studies, as it allows for detailed biochemical and biophysical analyses. Such work can provide insights into the protein's functional domains and interaction partners, paving the way for novel interventions in dyslipidemia and related disorders. As the understanding of LDLRAD3 continues to evolve, it holds promise for contributing to strategies aimed at improving cardiovascular health and developing innovative treatments for metabolic diseases.
