Analytical Data
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Gene name
ATP1b4
- Application
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Alternative Names
ATP1b4；Protein ATP1B4
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Species
Human
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Source
E. coli
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Tag
His tag N-Terminus
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
Q9UN42
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Expression Region
1-357aa
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AA Sequence
MRRQLRSRRAPSFPYSYRYRLDDPDEANQNYLADEEEEAEEEARVTVVPKSEEEEEEEEKEEEEEEEKEEEEGQGQPTGNAWWQKLQIMSEYLWDPERRMFLARTGQSWSLILLIYFFFYASLAAVITLCMYTLFLTISPYIPTFTERVKPPGVMIRPFAHSLNFNFNVSEPDTWQHYVISLNGFLQGYNDSLQEEMNVDCPPGQYFIQDGNEDEDKKACQFKRSFLKNCSGLEDPTFGYSTGQPCILLKMNRIVGFRPELGDPVKVSCKVQRGDENDIRSISYYPESASFDLRYYPYYGKLTHVNYTSPLVAMHFTDVVKNQAVPVQCQLKGKGVINDVINDRFVGRVIFTLNIET
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Molecular Weight
41.5 kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
Related Products
Protein Description
ATP1b4 is a member of the ATPase family, specifically belonging to the Na+/K+ ATPase subunit family, which plays a critical role in maintaining cellular ion homeostasis and electrical excitability in various tissues. The ATP1b4 gene encodes the beta 4 subunit of the Na+/K+ pump, which is essential for the enzyme's functionality and stability. Research has indicated that ATP1b4 is particularly important in specific neuronal populations and may contribute to neurological processes. Understanding the structure and function of ATP1b4 can provide insights into its role in health and disease. Furthermore, the development of recombinant ATP1b4 protein allows for detailed biochemical and biophysical studies, facilitating investigations into its interactions with the alpha subunit and other cellular components. This research is vital for elucidating the physiological and pathological roles of ATP1b4 in disorders such as epilepsy and other neurological conditions where ion balance and membrane potential are disrupted. Overall, the study of recombinant ATP1b4 not only enhances our understanding of Na+/K+ ATPase activity but also paves the way for potential therapeutic strategies targeting ion channel dysfunction in neurological diseases.
