Analytical Data
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Gene name
RARb
- Application
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Alternative Names
RARb；HAP；NR1B2；Retinoic acid receptor beta
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Species
Human
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Source
E. coli
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Tag
His tag N-Terminus
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
P10826
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Expression Region
1-455aa
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AA Sequence
MTTSGHACPV PAVNGHMTHY PATPYPLLFP PVIGGLSLPP LHGLHGHPPP SGCSTPSPAT IETQSTSSEE LVPSPPSPLP PPRVYKPCFV CQDKSSGYHY GVSACEGCKG FFRRSIQKNM IYTCHRDKNC VINKVTRNRC QYCRLQKCFE VGMSKESVRN DRNKKKKETS KQECTESYEM TAELDDLTEK IRKAHQETFP SLCQLGKYTT NSSADHRVRL DLGLWDKFSE LATKCIIKIV EFAKRLPGFT GLTIADQITL LKAACLDILI LRICTRYTPE QDTMTFSDGL TLNRTQMHNA GFGPLTDLVF TFANQLLPLE MDDTETGLLS AICLICGDRQ DLEEPTKVDK LQEPLLEALK IYIRKRRPSK PHMFPKILMK ITDLRSISAK GAERVITLKM EIPGSMPPLI QEMLENSEGH EPLTPSSSGN TAEHSPSISP SSVENSGVSQ SPLVQ
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Molecular Weight
50.4 kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
Related Products
Protein Description
RARb (Retinoic Acid Receptor beta) is a member of the nuclear receptor superfamily and plays a crucial role in regulating gene expression in response to retinoic acid, a metabolite of vitamin A. Research on RARb has garnered significant attention due to its involvement in various biological processes, including cell differentiation, proliferation, and apoptosis. Moreover, RARb has been implicated in several pathological conditions, such as cancer, where its expression is often downregulated or mutated, contributing to tumorigenesis. In particular, RARb is recognized for its potential as a therapeutic target, as restoring its function may inhibit tumor growth and enhance the efficacy of existing cancer treatments. The study of RARb involves not only the exploration of its molecular mechanisms but also the development of recombinant proteins for functional assays, which can provide insights into its interactions with other proteins and regulatory elements. Hence, researchers are focusing on the production and characterization of RARb recombinant proteins to better understand its role in cellular signaling pathways and its potential applications in targeted therapies. The growing body of evidence linking RARb to critical biological functions and disease processes highlights the importance of this area of research, positioning RARb as a significant player in the realm of molecular biology and translational medicine.
