Analytical Data
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基因名
MCM7
- Application
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别名
MCM7;CDC47;MCM2;DNA replication licensing factor MCM7
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种属
Human
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表达系统
E. coli
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标签
His tag N-Terminus
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
P33993-2
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表达区间
1-389aa
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氨基酸序列
MALKDYALEKEKVKKFLQEFYQDDELGKKQFKYGNQLVRLAHREQVALYV DLDDVAEDDPELVDSICENARRYAKLFADAVQELLPQYKEREVVNKDVLD VYIEHRLMMEQRSRDPGMVRSPQNQYPAELMRRFELYFQGPSSSKPRVIR EVRADSVGKLVTVRGIVTRVSEVKPKMVVATYTCDQCGAETYQPIQSPTF MPLIMCPSQECQTNRSGGRLYLQTRGSRFIKFQEMKMQEHSDQVPVGNIP RSITVLVEGENTRIAQPGDHVSVTGIFLPILRTGFRQVVQGLLSETYLEA HRIVKMNKSEDDESGAGELTREELRQIADVIFATVRELVSGGRSVRFSEA EQRCVSRGFTPAQFQAALDEYEELNVWQVNASRTRITFV
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分子量
69 kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
MCM7, or Minichromosome Maintenance 7, is a key protein involved in DNA replication and cell cycle regulation. As a member of the MCM protein complex, it plays a crucial role in the initiation of DNA replication by unwinding the double helix, allowing for the synthesis of new DNA strands. Dysregulation of MCM7 has been implicated in various cancers, making it a significant focus of research in cancer biology. Understanding the structure and function of MCM7 is essential for elucidating its role in oncogenesis and for developing potential therapeutic strategies. Recent studies have explored the expression patterns of MCM7 in tumor tissues and its correlation with cancer progression, highlighting its potential as a biomarker for cancer diagnosis and prognosis. Additionally, investigations into MCM7's interactions with other cellular proteins and its regulation during the cell cycle have provided insights into the complex mechanisms governing cellular proliferation. The reconstitution of MCM7 as a recombinant protein allows for in-depth biochemical assays and structural studies, facilitating a better understanding of its function and interactions. This research not only contributes to our fundamental knowledge of DNA replication but also opens avenues for targeted therapies that could disrupt the function of MCM7 in cancer cells, offering hope for more effective cancer treatments.
