Analytical Data
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Gene name
KRT6IRS
- Application
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Alternative Names
CK-71; Cytokeratin-71; hK6irs; hK6irs1; K2C71_HUMAN; K6IRS1; K71; KB34; Keratin 6 irs; Keratin 6. inner root sheath. 1; Keratin; keratin. type II cytoskeletal 71; Keratin-71; KRT6IRS; KRT6IRS1; KRT71; MGC119390; MGC119391; OTTHUMP00000236990; type II cytoskeletal 71; Type II inner root sheath-specific keratin-K6irs1; Type-II keratin Kb34
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Species
Human
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Source
E. coli
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Tag
GST-tag at N-terminal
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
Q3SY84
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Expression Region
1-523aa
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AA Sequence
MSRQFTCKSGAAAKGGFSGCSAVLSGGSSSSFRAGSKGLSGGFGSRSLYSLGGVRSLNVASGSGKSGGYGFGRGRASGFAGSMFGSVALGPVCPTVCPPGGIHQVTVNESLLAPLNVELDPEIQKVRAQEREQIKALNNKFASFIDKVRFLEQQNQVLETKWELLQQLDLNNCKNNLEPILEGYISNLRKQLETLSGDRVRLDSELRNVQDVVEDYKKRYEEEINKRTAAENEFVLLKKDVDAAYANKVELQAKVESMDQEIKFFRCLFEAEITQIQSHISDMSVILSMDNNRNLDLDSIIDEVRTQYEEIALKSKAEAEALYQTKFQELQLAAGRHGDDLKNTKNEISELTRLIQRIRSEIENVKKQASNLETAIADAEQRGDNALKDARAKLDELEGALHQAKEELARMLREYQELMSLKLALDMEIATYRKLLESEECRMSGEFPSPVSISIISSTSGGSGYGFRPSMVSGGYVANSSNCISGVCSVRGGEGRSRGSANDYKDTLGKGSSLSAPSKKTSR
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Molecular Weight
83.6 kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
The KRT6IRS protein, a keratin intermediate filament protein, is significant in the study of epithelial development and pathology. Keratins are essential structural proteins that play crucial roles in maintaining cellular integrity and protecting against mechanical stress. The KRT6 family, particularly KRT6A, KRT6B, and KRT6C, is notably expressed in areas subjected to frequent friction and injury, such as the skin, oral cavity, and hair follicles. Research has highlighted KRT6's involvement in various skin disorders, including psoriasis and other inflammatory conditions. Moreover, KRT6 is implicated in the cellular response to stress and injury, as its expression is upregulated in wound healing processes. Understanding the molecular mechanisms governing KRT6IRS's function and regulation may provide insights into epithelial cell biology and the etiology of associated diseases. Furthermore, with advancements in recombinant technology, the generation of recombinant KRT6IRS protein allows for in-depth studies, enabling researchers to explore its structural properties, interactions with other proteins, and potential therapeutic applications. The ongoing research into KRT6IRS is promising, paving the way for developing targeted interventions for keratin-related diseases and improving our understanding of epithelial biology.
