Analytical Data
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基因名
Lnk
- Application
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别名
Lnk；LNK；SH2B adapter Protein 3
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种属
Human
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表达系统
E. coli
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标签
His tag N-Terminus
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
Q9UQQ2
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表达区间
1-575aa
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氨基酸序列
MNGPALQPSS PSSAPSASPA AAPRGWSEFC ELHAVAAARE LARQYWLFAR EHPQHAPLRA ELVSLQFTDL FQRYFCREVR DGRAPGRDYR DTGRGPPAKA EASPEPGPGP AAPGLPKARS SEELAPPRPP GPCSFQHFRR SLRHIFRRRS AGELPAAHTA AAPGTPGEAA ETPARPGLAK KFLPWSLARE PPPEALKEAV LRYSLADEAS MDSGARWQRG RLALRRAPGP DGPDRVLELF DPPKSSRPKL QAACSSIQEV RWCTRLEMPD NLYTFVLKVK DRTDIIFEVG DEQQLNSWMA ELSECTGRGL ESTEAEMHIP SALEPSTSSS PRGSTDSLNQ GASPGGLLDP ACQKTDHFLS CYPWFHGPIS RVKAAQLVQL QGPDAHGVFL VRQSETRRGE YVLTFNFQGI AKHLRLSLTE RGQCRVQHLH FPSVVDMLHH FQRSPIPLEC GAACDVRLSS YVVVVSQPPG SCNTVLFPFS LPHWDSESLP HWGSELGLPH LSSSGCPRGL SPEGLPGRSS PPEQIFHLVP SPEELANSLQ HLEHEPVNRA RDSDYEMDSS SRSHLRAIDN QYTPL
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分子量
63.2 kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
Lnk, also known as SH2B3, is a crucial adaptor protein that plays a significant role in signal transduction pathways linked to hematopoiesis and immune response. It is primarily expressed in hematopoietic cells and serves as a negative regulator in various signaling cascades, particularly those initiated by cytokines and growth factors. The research on Lnk has gained momentum due to its implications in various diseases, including hematological malignancies, obesity, and autoimmune disorders. Studies have shown that Lnk interacts with multiple signaling partners, modulating pathways such as the JAK-STAT and PI3K-AKT pathways, which are vital for cell proliferation and survival. Understanding the molecular mechanisms underlying Lnk's functions could provide insight into its role in disease processes. Recent investigations have focused on the structural properties of Lnk, including its phosphorylation states and interactions with other proteins, which may reveal potential therapeutic targets. Given its pivotal role in regulating immune responses and cell signaling, Lnk is a promising candidate for further research, aimed at elucidating its contributions to both normal physiology and pathological conditions.
