Analytical Data
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基因名
PIK3C2b
- Application
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别名
PIK3C2b；HER2；MLN19；NEU；Receptor tyrosine-Protein kinase erbB-2
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种属
Human
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表达系统
E. coli
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标签
His tag N-Terminus
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
B7ZM86
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表达区间
850-1606aa
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氨基酸序列
WTHMNHQDAL GLLHATFPDQ EVRRMAVQWI GSLSDAELLD YLPQLVQALK YECYLDSPLV RFLLKRAVSD LRVTHYFFWL LKDGLKDSQF SIRYQYLLAA LLCCCGKGLR EEFNRQCWLV NALAKLAQQV REAAPSARQG ILRTGLEEVK QFFALNGSCR LPLSPSLLVK GIVPRDCSYF NSNAVPLKLS FQNVDPLGEN IRVIFKCGDD LRQDMLTLQM IRIMSKIWVQ EGLDMRMVIF RCFSTGRGRG MVEMIPNAET LRKIQVEHGV TGSFKDRPLA DWLQKHNPGE DEYEKAVENF IYSCAGCCVA TYVLGICDRH NDNIMLKTTG HMFHIDFGRF LGHAQMFGNI KRDRAPFVFT SDMAYVINGG DKPSSRFHDF VDLCCQAYNL IRKHTHLLLN LLGLMLSCGI PELSDLEDLK YVYDALRPQD TEANATTYFT RLIESSLGSV ATKLNFFIHN LAQMKFTGSD DRLTLSFASR THTLKSSGRI SDVFLCRHEK IFHPNKGYIY VVKVMRENTH EATYIQRTFE EFQELHNKLR LLFPSSHLPS FPSRFVIGRS RGEAVAERRR EELNGYIWHL IHAPPEVAEC DLVYTFFHPL PRDEKAMGTS PAPKSSDGTW ARPVGKVGGE VKLSISYKNN KLFIMVMHIR GLQLLQDGND PDPYVKIYLL PDPQKTTKRK TKVARKTCNP TYNEMLVYDG IPKGDLQQRE LQLSVLSEQG FWENVLLGEV NIRLRELDLA QEKTGWFALG SRSHGTL
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分子量
98 kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
PIK3C2b, a member of the class II phosphoinositide 3-kinase (PI3K) family, plays a critical role in cellular processes such as lipid metabolism, membrane trafficking, and cytoskeletal dynamics. Unlike its class I counterparts, PIK3C2b primarily generates phosphatidylinositol 3-phosphate (PI3P), which is essential for the regulation of endocytosis and the maturation of endosomal compartments. Recent studies have highlighted the involvement of PIK3C2b in various physiological and pathological contexts, including cancer progression, insulin signaling, and neurological disorders. The reconstitution of PIK3C2b as a recombinant protein allows for detailed biochemical characterization and the exploration of its functional mechanisms. This approach aids in understanding the specific interactions of PIK3C2b with other cellular components and its role in signaling pathways. Furthermore, investigating the enzymatic activity and substrate specificity of PIK3C2b could reveal potential therapeutic targets for diseases linked to aberrant PI3K signaling. Overall, research on PIK3C2b is crucial for elucidating its contributions to cellular homeostasis and developing strategies to modulate its activity in disease contexts.
