Analytical Data
-
Gene name
KLHL10
- Application
-
Alternative Names
KLHL10Kelch-like protein 10
-
Species
Human
-
Source
E. coli
-
Tag
GST-tag at N-terminal
-
Purity
Greater than 90% as determined by SDS-PAGE.
-
Uniprot
Q6JEL2
-
Expression Region
1-608aa
-
AA Sequence
MEMESAAASTRFHQPHMERKMSAMACEIFNELRLEGKLCDVVIKVNGFEFSAHKNILCSCSSYFRALFTSGWNNTEKKVYNIPGISPDMMKLIIEYAYTRTVPITPDNVEKLLAAADQFNIMGIVRGCCEFLKSELCLDNCIGICKFTDYYYCPELRQKAYMFILHNFEEMVKVSAEFLELSVTELKDIIEKDELNVKQEDAVFEAILKWISHDPQNRKQHISILLPKVRLALMHAEYFMNNVKMNDYVKDSEECKPVIINALKAMYDLNMNGPSNSDFTNPLTRPRLPYAILFAIGGWSGGSPTNAIEAYDARADRWVNVTCEEESPRAYHGAAYLKGYVYIIGGFDSVDYFNSVKRFDPVKKTWHQVAPMHSRRCYVSVTVLGNFIYAMGGFDGYVRLSTAERYEPETNQWTLIAPMHEQRSDASATTLYGKVYICGGFNGNECLFTAEVYNTESNQWTVIAPMRSRRSGIGVIAYGEHVYAVGGFDGANRLRSAEAYSPVANTWRTIPTMFNPRSNFGIEVVDDLLFVVGGFNGFTTTFNVECYDEKTDEWYDAHDMSIYRSALSCCVVPGLANVEEYAARRDNFPGLELRDEVKYSASTSTLPV
-
Molecular Weight
95.4 kDa
-
Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
-
Form
Freeze-dried powder
-
Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
-
Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
-
Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
-
Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
-
Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
Related Products
Protein Description
KLHL10 (Kelch-like 10) is a member of the Kelch-like protein family, which is known for its role in various cellular processes, including protein stabilization, ubiquitination, and signal transduction. Recent studies have implicated KLHL10 in several critical biological functions, including cell cycle regulation and cellular response to stress. Its dysfunction has been linked to various pathologies, including cancer and neurodegenerative diseases, making it a protein of significant interest in medical research. The ability of KLHL10 to interact with different substrates suggests that it may act as a modulator of various signaling pathways, potentially influencing tumorigenesis and the progression of various diseases. Researchers are now focusing on the characterization of KLHL10 recombinant proteins, aiming to elucidate its structure-function relationships and mechanistic roles in cellular pathways. The study of KLHL10's recombinant forms could provide insights into its potential as a therapeutic target and help develop strategies to manipulate its activity for clinical benefit. Understanding the precise functions and interactions of KLHL10 is crucial for leveraging its potential in innovative treatments for diseases associated with its dysregulation.
