Analytical Data
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Gene name
LSM5
- Application
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Alternative Names
LSM5;U6 snRNA-associated Sm-like Protein LSm5
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Species
Human
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Source
E. coli
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Tag
His tag N-Terminus
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
Q9Y4Y9
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Expression Region
1-91aa
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AA Sequence
MGSSHHHHHH SSGLVPRGSH MGSMAANATT NPSQLLPLEL VDKCIGSRIH IVMKSDKEIV GTLLGFDDFV NMVLEDVTEF EITPEGRRIT KLDQILLNGN NITMLVPGGE GPEV
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Molecular Weight
12 kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
LSM5 is a protein complex that plays a critical role in mRNA processing and regulation in eukaryotic cells. It is comprised of several subunits, including LSM proteins, which are essential for mRNA stabilization, decapping, and degradation processes. The research background of LSM5 is rooted in understanding its function in the context of RNA metabolism, particularly how it interacts with other RNA-binding proteins and cellular pathways. Studies have shown that LSM5 is involved in the life cycle of mRNA, from transcription to translation, and its dysregulation can lead to various cellular dysfunctions and diseases, including cancer. Furthermore, LSM5 has been implicated in responses to environmental stresses, highlighting its importance in cellular adaptation and survival. Research on LSM5 focuses on elucidating its molecular mechanisms, determining its role in mRNA turnover, and exploring its potential as a therapeutic target. Understanding LSM5 is crucial for comprehending the complexities of gene expression regulation and its implications in human health and disease.
