Analytical Data
-
Gene name
LAMTOR4
- Application
-
Alternative Names
LAMTOR4;C7orf59;Ragulator complex Protein LAMTOR4
-
Species
Human
-
Source
E. coli
-
Tag
His tag N-Terminus
-
Purity
Greater than 90% as determined by SDS-PAGE.
-
Uniprot
Q0VGL1
-
Expression Region
1-99aa
-
AA Sequence
MGSSHHHHHH SSGLVPRGSH MGSMTSALTQ GLERIPDQLG YLVLSEGAVL ASSGDLENDE QAASAISELV STACGFRLHR GMNVPFKRLS VVFGEHTLLV TVSGQRVFVV KRQNRGREPI DV
-
Molecular Weight
13 kDa
-
Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
-
Form
Freeze-dried powder
-
Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
-
Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
-
Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
-
Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
-
Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
Related Products
Protein Description
LAMTOR4, a key component of the late endosomal/lysosomal microdomain, plays a crucial role in the regulation of cellular signaling and nutrient sensing pathways. Recent studies have highlighted its importance in the mTOR (mechanistic target of rapamycin) signaling pathway, which is pivotal for cellular growth and metabolism. Dysregulation of LAMTOR4 has been implicated in various diseases, including cancer and metabolic disorders, making it a potential therapeutic target. Understanding the structure and function of LAMTOR4 is critical, as it interacts with multiple proteins within the lysosomal complex, influencing autophagy and lysosomal function. Recombining LAMTOR4 as a protein for research purposes allows for in-depth studies of its role in cellular processes and offers insights into how its modulation could impact disease progression. Enhanced comprehension of LAMTOR4's mechanisms may also contribute to the development of innovative treatments aimed at correcting the signaling imbalances observed in associated diseases. Thus, characterizing LAMTOR4 through recombinant protein studies is not only essential for basic biological science but also has significant implications for the advancement of targeted therapies.
