Analytical Data
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基因名
KIAA1333
- Application
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别名
G2E3. KIAA1333
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种属
Human
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表达系统
E. coli
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标签
GST-tag at N-terminal
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
Q7L622
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表达区间
1-706aa
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氨基酸序列
MNESKPGDSQNLACVFCRKHDDCPNKYGEKKTKEKWNLTVHYYCLLMSSGIWQRGKEEEGVYGFLIEDIRKEVNRASKLKCCVCKKNGASIGCVAPRCKRSYHFPCGLQRECIFQFTGNFASFCWDHRPVQIITSNNYRESLPCTICLEFIEPIPSYNILRSPCCKNAWFHRDCLQVQAINAGAFFFRCTICNNSDIFQKEMLRMGIHIPEKDASWELEENAYQELLQHYERCDVRRCRCKEGRDYNAPDSKWEIKRCQCCGSSGTHLACSSLRSWEQNWECLECRGIIYNSGEFQKAKKHVLPNSNNVGITDCLLEESSPKLPRQSPGSQSKDLLRQGSKFRRNVSTLLIELGFQIKKKTKRLYINKANIWNSALDAFRNRNFNPSYAIEVAYVIENDNFGSEHPGSKQEFLSLLMQHLENSSLFEGSLSKNLSLNSQALKENLYYEAGKMLAISLVHGGPSPGFFSKTLFNCLVYGPENTQPILDDVSDFDVAQIIIRINTATTVADLKSIINECYNYLELIGCLRLITTLSDKYMLVKDILGYHVIQRVHTPFESFKQGLKTLGVLEKIQAYPEAFCSILCHKPESLSAKILSELFTVHTLPDVKALGFWNSYLQAVEDGKSTTTMEDILIFATGCSSIPPAGFKPTPSIECLHVDFPVGNECNNCLAIPITNTYKEFQENMDFTIRNTLRLEKEESSHYIGH
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分子量
106.9 kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
KIAA1333, also known as C9orf72 interacting protein, has garnered attention in recent years due to its potential role in neurodegenerative diseases, particularly in the context of amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD). The protein is believed to be involved in cellular processes such as endosomal trafficking and autophagy, contributing to neuronal health and longevity. Genetic studies have linked KIAA1333 with the pathological pathways associated with the expansion of the C9orf72 gene, which is the most common genetic cause of familial ALS and FTD. Furthermore, KIAA1333 has been shown to interact with various proteins involved in RNA metabolism and stress granule assembly, suggesting its role in the cellular response to stress. Understanding the function and mechanisms of KIAA1333 is crucial for elucidating the molecular underpinnings of neurodegeneration and could potentially pave the way for novel therapeutic strategies aimed at mitigating the effects of these debilitating diseases. As research continues, the focus on KIAA1333 promises to unveil new insights into the complex interactions and pathways that contribute to neuronal death and dysfunction, making it a significant target for future studies in the field of neurobiology.
