Analytical Data
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基因名
ATXN2
- Application
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别名
ATXN2；ATX2；SCA2；TNRC13；Ataxin-2
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种属
Human
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表达系统
E. coli
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标签
His tag N-Terminus
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
Q99700
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表达区间
481-775aa
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氨基酸序列
REGHSINTRENKYIPPGQRNREVISWGSGRQNSPRMGQPGSGSMPSRSTSHTSDFNPNSGSDQRVVNGGVPWPSPCPSPSSRPPSRYQSGPNSLPPRAATPTRPPSRPPSRPSRPPSHPSAHGSPAPVSTMPKRMSSEGPPRMSPKAQRHPRNHRVSAGRGSISSGLEFVSHNPPSEAATPPVARTSPSGGTWSSVVSGVPRLSPKTHRPRSPRQNSIGNTPSGPVLASPQAGIIPTEAVAMPIPAASPTPASPASNRAVTPSSEAKDSRLQDQRQNSPAGNKENIKPNETSPSF
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分子量
37.0 kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
ATXN2, or Ataxin-2, is a protein encoded by the ATXN2 gene, and it plays a crucial role in various cellular processes, including RNA metabolism, stress granule formation, and neuronal function. Mutations or expansions in the CAG repeat region of the ATXN2 gene are associated with spinocerebellar ataxia type 2 (SCA2), a neurodegenerative disorder characterized by progressive ataxia. The research surrounding ATXN2 recombinant protein has gained significant attention due to its implications in disease pathology and potential therapeutic avenues. Studying the structure and function of ATXN2 can provide insights into the molecular mechanisms underlying SCA2 and other neurodegenerative diseases. Furthermore, recombinant ATXN2 can be utilized in biochemical assays, helping to identify potential interactors and elucidate its role in neuronal health. Understanding the dynamics of ATXN2 also contributes to broader research on polyglutamine diseases, as it can reveal common pathways involved in neurodegeneration. Overall, the exploration of ATXN2 recombinant protein stands as a pivotal area of research in molecular biology and neurodegeneration, opening up prospects for targeted treatments and better understanding of the intricate networks involved in neuronal homeostasis.
