Analytical Data
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基因名
KRT8
- Application
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别名
KRT38;HHA8;HKA8;KRTHA8;Keratin. type I cuticular Ha8
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种属
Human
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表达系统
E. coli
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标签
His tag N-Terminus
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
P05787
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表达区间
1-483aa
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氨基酸序列
MGSSHHHHHHSSGLVPRGSHMGSMSIRVTQKSYKVSTSGPRAFSSRSYTS GPGSRISSSSFSRVGSSNFRGGLGGGYGGASGMGGITAVTVNQSLLSPLV LEVDPNIQAVRTQEKEQIKTLNNKFASFIDKVRFLEQQNKMLETKWSLLQ QQKTARSNMDNMFESYINNLRRQLETLGQEKLKLEAELGNMQGLVEDFKN KYEDEINKRTEMENEFVLIKKDVDEAYMNKVELESRLEGLTDEINFLRQL YEEEIRELQSQISDTSVVLSMDNSRSLDMDSIIAEVKAQYEDIANRSRAE AESMYQIKYEELQSLAGKHGDDLRRTKTEISEMNRNISRLQAEIEGLKGQ RASLEAAIADAEQRGELAIKDANAKLSELEAALQRAKQDMARQLREYQEL MNVKLALDIEIATYRKLLEGEESRLESGMQNMSIHTKTTSGYAGGLSSAY GGLTSPGLSYSLGSSFGSGAGSSSFSRTSSSRAVVVKKIETRDGKLVSES SDVLPK
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分子量
56 kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
Keratin 8 (KRT8) is a crucial intermediate filament protein predominantly expressed in simple epithelial cells and plays a significant role in maintaining cell structure and function. Research on KRT8 has gained momentum due to its involvement in various cellular processes, including apoptosis, differentiation, and response to stress. Abnormal expression of KRT8 has been linked to several pathological conditions, including liver diseases, cancers, and other forms of epithelial dysfunction. Studies have shown that KRT8 can act as a marker for certain cancer types, offering potential diagnostic and therapeutic avenues. Additionally, the understanding of KRT8's role in cellular signaling and tissue integrity has highlighted its importance in developmental biology and regenerative medicine. The recombinant expression of KRT8 in different systems allows for detailed analysis of its functional properties and interactions with other proteins, facilitating a deeper understanding of its biological roles. This research is essential for developing targeted therapies and improving clinical outcomes for diseases associated with keratin abnormalities.
