Analytical Data
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基因名
KIAA1199
- Application
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别名
CEMIP; KIAA1199; Cell migration-inducing and hyaluronan-binding protein; EC 3.2.1.35
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种属
Human
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表达系统
E. coli
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标签
GST-tag at N-terminal
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
Q8WUJ3
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表达区间
880-979aa
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氨基酸序列
LYDGPINIQNCTFRKFVALEGRHTSALAFRLNNAWQSCPHNNVTGIAFEDVPITSRVFFGEPGPWFNQLDMDGDKTSVFHDVDGSVSEYPGSYLTKNDNW
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分子量
36.74 kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
KIAA1199 is a protein that has garnered significant attention in recent years due to its potential roles in various biological processes and diseases, particularly in cancer. Initially identified as a gene of unknown function, KIAA1199 has been implicated in tumorigenesis and cancer progression, especially in colorectal cancer. Its expression is often dysregulated in cancer tissues, suggesting a role in promoting cell proliferation, migration, and invasion. Studies have shown that KIAA1199 can interact with components of the extracellular matrix and influence cellular signaling pathways, thereby affecting tumor microenvironment interactions. Additionally, the protein has been associated with the epithelial-mesenchymal transition (EMT), a critical process in cancer metastasis. Recent research indicates that KIAA1199 may also be involved in the biosynthesis and secretion of hyaluronic acid, a component that enhances tumor growth and metastasis. The investigation of KIAA1199 offers potential for developing novel therapeutic strategies and biomarkers for cancer diagnosis and prognosis. Given its multifaceted roles in cancer biology, ongoing studies are focused on elucidating the precise molecular mechanisms underlying its function and exploring its potential as a target for cancer therapy. Understanding the role of KIAA1199 in various cellular contexts may not only provide insights into its contributions to tumor behavior but also aid in the development of new intervention strategies in oncology.
