Analytical Data
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基因名
KIR2DL3
- Application
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别名
HLA-C;HLAC;HLA class I histocompatibility antigen. C alpha chain
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种属
Human
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表达系统
E. coli
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标签
His tag N-Terminus
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
P43628
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表达区间
22-245aa
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氨基酸序列
HEGVHRKPSL LAHPGPLVKS EETVILQCWS DVRFQHFLLH REGKFKDTLH LIGEHHDGVS KANFSIGPMM QDLAGTYRCY GSVTHSPYQL SAPSDPLDIV ITGLYEKPSL SAQPGPTVLA GESVTLSCSS RSSYDMYHLS REGEAHERRF SAGPKVNGTF QADFPLGPAT HGGTYRCFGS FRDSPYEWSN SSDPLLVSVT GNPSNSWPSP TEPSSETGNP RHLH
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分子量
53 kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
KIR2DL3 is a member of the killer immunoglobulin-like receptor (KIR) family, which plays a crucial role in the regulation of natural killer (NK) cell responses in the immune system. KIR2DL3 specifically interacts with human leukocyte antigen (HLA) class I molecules, influencing the activation and inhibition of NK cells during immune responses, particularly in the context of viral infections and tumor surveillance. Research into the recombinant protein of KIR2DL3 has gained significance due to its potential applications in immunotherapy and vaccine development. Understanding the structural and functional properties of KIR2DL3 can provide insights into how NK cells recognize and respond to affected cells, enhancing our knowledge of immune regulation. Furthermore, the expression of KIR2DL3 can vary among individuals due to genetic polymorphisms, making its study relevant in understanding susceptibility to diseases and the effectiveness of immunotherapeutic strategies. Investigating KIR2DL3 at a molecular level through recombinant protein studies allows researchers to elucidate its binding capabilities and interactions with HLA molecules, thus contributing to the development of novel therapeutic approaches that harness the capabilities of the immune system. This research is particularly vital as it intersects with ongoing efforts to improve therapeutic interventions against cancers and chronic infections, highlighting the broader implications of KIR2DL3 in precision medicine and personalized immunotherapy.
