Analytical Data
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Gene name
COG5
- Application
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Alternative Names
COG5；GOLTC1；GTC90；Conserved oligomeric Golgi complex subunit 5
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Species
Human
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Source
E. coli
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Tag
His tag N-Terminus
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
Q9UP83
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Expression Region
1-257aa
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AA Sequence
MGWVGGRRRDSASPPGRSRSAADDINPAPANMEGGGGSVAVAGLGARGSGAAAATVRELLQDGCYSDFLNEDFDVKTYTSQSIHQAVIAEQLAKLAQGISQLDRELHLQVVARHEDLLAQATGIESLEGVLQMMQTRIGALQGAVDRIKAKIVEPYNKIVARTAQLARLQVACDLLRRIIRILNLSKRLQGQLQGGSREITKAAQSLNELDYLSQGIDLSGIEVIENDLLFIARARLEVENQAKRLLEQGLETQNPT
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Molecular Weight
33.8 kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
Related Products
Protein Description
COG5 (Conserved Oligomeric Golgi complex subunit 5) is a crucial component of the COG complex, which plays a significant role in intracellular protein trafficking and maintenance of Golgi apparatus structure. The COG complex is essential for the retrograde transport of proteins from the late Golgi to earlier compartments, ensuring proper glycosylation and sorting of proteins. Research on COG5 has garnered attention due to its implication in various cellular processes and its association with human diseases. Mutations in COG5 have been linked to inherited disorders, such as Congenital Disorders of Glycosylation, which can lead to severe developmental and neurological issues. As a result, understanding the structure, function, and regulatory mechanisms of COG5 is paramount for uncovering the molecular basis of these diseases. Recent studies leveraging recombinant DNA technology have enabled the production of COG5 in heterologous systems, providing opportunities for in-depth functional analysis and high-resolution structural studies. These insights are vital for elucidating the role of COG5 in Golgi apparatus dynamics and its broader implications in health and disease. Through targeted research, scientists aim to develop potential therapeutic strategies for conditions associated with COG5 dysfunction.
