Recombinant Human ISG15 Protein，His

ISG15 (Interferon Stimulated Gene 15) is a ubiquitin-like protein that plays a crucial role in the immune response, particularly during viral infections. It is an interferon-inducible protein, meaning its expression is significantly upregulated in response to interferon signaling, a key mechanism of the innate immune system. The research on ISG15 focuses on its role in the post-translational modification of target proteins through a process known as ISGylation, which is similar to ubiquitination but involves the conjugation of ISG15 instead. This modification has been shown to influence various cellular processes, including antiviral defense, cell signaling, and protein stability. Moreover, ISG15 is secreted by infected cells and can initiate immune responses in neighboring cells, contributing to its significance in host defense. Studies have revealed that ISG15 can modulate the activity of numerous proteins, including those involved in immune signaling pathways, suggesting its potential utility in therapeutic interventions against infections and cancer. The understanding of ISG15's mechanisms and functions may pave the way for novel strategies in antiviral therapies, enhancing our ability to manipulate the immune system for better disease management. Consequently, the recombinant production of ISG15 protein has become a focus of research, enabling the study of its structure and interactions, and potentially leading to the development of ISG15-based therapies in immunology and oncology.