Analytical Data
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基因名
KCTD12
- Application
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别名
13orf2; BTB/POZ domain-containing protein KCTD12; KCD12_HUMAN; KCTD12; KIAA1778; PFET1; Pfetin; potassium channel tetramerisation domain containing 12 USA ; Predominantly fetal expressed T1 domain
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种属
Human
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表达系统
E. coli
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标签
GST-tag at N-terminal
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
Q96CX2
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表达区间
1-325aa
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氨基酸序列
MALADSTRGLPNGGGGGGGSGSSSSSAEPPLFPDIVELNVGGQVYVTRRCTVVSVPDSLLWRMFTQQQPQELARDSKGRFFLDRDGFLFRYILDYLRDLQLVLPDYFPERSRLQREAEYFELPELVRRLGAPQQPGPGPPPSRRGVHKEGSLGDELLPLGYSEPEQQEGASAGAPSPTLELASRSPSGGAAGPLLTPSQSLDGSRRSGYITIGYRGSYTIGRDAQADAKFRRVARITVCGKTSLAKEVFGDTLNESRDPDRPPERYTSRYYLKFNFLEQAFDKLSESGFHMVACSSTGTCAFASSTDQSEDKIWTSYTEYVFCRE
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分子量
62.1 kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
KCTD13 (Potassium Channel Tetramerization Domain Containing 13) is a protein that has gained attention in recent years due to its association with neurodevelopmental disorders, particularly autism spectrum disorder (ASD). Studies have shown that mutations or disruptions in the KCTD13 gene can lead to dysregulation of synaptic function and neuronal development, implicating it as a critical player in brain functionality and connectivity. The protein functions primarily as an antagonist of the mammalian target of rapamycin (mTOR) signaling pathway, which is pivotal in regulating cell growth and metabolism. Furthermore, KCTD13 has been demonstrated to interact with various proteins involved in scaffolding and signaling, suggesting its role in maintaining cellular homeostasis. Recombinant expression of KCTD13 helps in elucidating its molecular mechanisms and functional roles in neuronal cultures, providing insights into its contribution to synaptic physiology. Understanding KCTD13’s structure and interactions can aid in the development of therapeutic strategies for conditions linked to its dysfunction. Given the increasing prevalence of neurodevelopmental disorders, research focused on KCTD13 and its implications in the nervous system is vital for advancing both basic science and clinical applications aimed at improving treatment outcomes for affected individuals.
