Analytical Data
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基因名
KCNK18
- Application
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别名
KCNK18; TRESK; TRIK; Potassium channel subfamily K member 18; TWIK-related individual potassium channel; TWIK-related spinal cord potassium channel
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种属
Human
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表达系统
E. coli
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标签
GST-tag at N-terminal
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
Q7Z418
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表达区间
1-384aa
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氨基酸序列
MEVSGHPQARRCCPEALGKLFPGLCFLCFLVTYALVGAVVFSAIEDGQVLVAADDGEFEKFLEELCRILNCSETVVEDRKQDLQGHLQKVKPQWFNRTTHWSFLSSLFFCCTVFSTVGYGYIYPVTRLGKYLCMLYALFGIPLMFLVLTDTGDILATILSTSYNRFRKFPFFTRPLLSKWCPKSLFKKKPDPKPADEAVPQIIISAEELPGPKLGTCPSRPSCSMELFERSHALEKQNTLQLPPQAMERSNSCPELVLGRLSYSIISNLDEVGQQVERLDIPLPIIALIVFAYISCAAAILPFWETQLDFENAFYFCFVTLTTIGFGDTVLEHPNFFLFFSIYIIVGMEIVFIAFKLVQNRLIDIYKNVMLFFAKGKFYHLVKK
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分子量
69.19 kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
KCNK18, also known as the K2P18.1 channel, is a member of the two-pore domain potassium channel family, which plays a crucial role in maintaining the resting membrane potential and regulating neuronal excitability. This channel is of particular interest due to its unique voltage and pH sensitivity characteristics, making it a potential candidate for novel therapeutic targets in the treatment of various neurological disorders and cardiovascular conditions. Research into KCNK18 has revealed its involvement in mechanisms such as ion homeostasis and cell signaling, which are vital for cellular functioning. Given its expression in the nervous system and potential implications in pain sensation and respiratory response, studies are increasingly focused on understanding its channel properties, subcellular localization, and biological functions. The production of recombinant KCNK18 proteins allows for detailed biophysical and pharmacological studies, providing insights into channel gating mechanisms and interactions with potential pharmacological agents. Such investigations could pave the way for the development of drugs aimed at modulating KCNK18 activity, thus offering new avenues for addressing diseases linked to potassium channel dysfunction. Understanding KCNK18 further enriches our knowledge of potassium channels and their role in health and disease, highlighting the significance of this research in the broader context of ion channel biology and therapeutic innovation.
