Analytical Data
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基因名
PEX19
- Application
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别名
PEX19；HK33；PXF；Peroxisomal biogenesis factor 19
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种属
Human
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表达系统
E. coli
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标签
His tag N-Terminus
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
P40855
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表达区间
1-296aa
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氨基酸序列
MGSSHHHHHHSSGLVPRGSHMAAAEEGCSVGAEADRELEELLESALDDFD KAKPSPAPPSTTTAPDASGPQKRSPGDTAKDALFASQEKFFQELFDSELA SQATAEFEKAMKELAEEEPHLVEQFQKLSEAAGRVGSDMTSQQEFTSCLK ETLSGLAKNATDLQNSSMSEEELTKAMEGLGMDEGDGEGNILPIMQSIMQ NLLSKDVLYPSLKEITEKYPEWLQSHRESLPPEQFEKYQEQHSVMCKICE QFEAETPTDSETTQKARFEMVLDLMQQLQDLGHPPKELAGEMPPGLNFDL DALNLSGPPGASGEQC
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分子量
35 kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
PEX19 is a key protein involved in the biogenesis and maintenance of peroxisomes, which are essential organelles responsible for various metabolic processes, including fatty acid oxidation and reactive oxygen species detoxification. Defects in peroxisomal functions can lead to severe metabolic disorders such as Zellweger syndrome and X-linked adrenoleukodystrophy. PEX19 functions as an import receptor, facilitating the transport of peroxisomal membrane proteins (PMPs) from the cytosol to the peroxisome membrane, a critical step in peroxisome assembly. Understanding the molecular mechanisms of PEX19 and its interactions with various PMPs is crucial for elucidating the pathways that govern peroxisome biogenesis and function. Recent studies have focused on characterizing the structure and dynamic behavior of PEX19, as well as its role in recognizing and binding to different PMPs. The exploration of PEX19 recombinant protein provides a valuable tool for biochemical assays and functional studies, contributing to a better understanding of its role in peroxisomal metabolism and the identification of potential therapeutic targets for related disorders. Advances in this research could ultimately pave the way for novel strategies in the treatment of peroxisomal diseases and enhance our knowledge of organelle biogenesis in general.
