Analytical Data
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基因名
KCNK12
- Application
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别名
KCNK12; Potassium channel subfamily K member 12; Tandem pore domain halothane-inhibited potassium channel 2; THIK-2
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种属
Human
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表达系统
E. coli
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标签
His tag N-Terminus
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
Q9HB15
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表达区间
1-430aa
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氨基酸序列
MSSRSPRPPPRRSRRRLPRPSCCCCCCRRSHLNEDTGRFVLLAALIGLYLVAGATVFSALESPGEAEARARWGATLRNFSAAHGVAEPELRAFLRHYEAALAAGVRADALRPRWDFPGAFYFVGTVVSTIGFGMTTPATVGGKAFLIAYGLFGCAGTILFFNLFLERIISLLAFIMRACRERQLRRSGLLPATFRRGSALSEADSLAGWKPSVYHVLLILGLFAVLLSCCASAMYTSVEGWDYVDSLYFCFVTFSTIGFGDLVSSQHAAYRNQGLYRLGNFLFILLGVCCIYSLFNVISILIKQVLNWMLRKLSCRCCARCCPAPGAPLARRNAITPGSRLRRRLAALGADPAARDSDAEGRRLSGELISMRDLTASNKVSLALLQKQLSETANGYPRSVCVNTRQNGFSGGVGALGIMNNRLAETSASR
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分子量
46.8 kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
KCNK12, also known as twin pore domain potassium channel 2 (TPM2), is a member of the K2P channel family, which plays a crucial role in maintaining the resting membrane potential and regulating cellular excitability. The KCNK12 gene encodes a potassium ion channel that is active at rest, contributing to the regulation of neuronal excitability and signal transduction. Research into KCNK12 has gained momentum due to its potential implications in various physiological processes and pathological conditions, including pain perception, respiratory function, and neurodevelopmental disorders. The interest in KCNK12 also stems from its unique biophysical properties, such as its ability to generate background potassium currents that can modulate the activity of other ion channels. Furthermore, its involvement in diseases, including certain types of cancer and psychiatric disorders, makes KCNK12 a promising target for therapeutic intervention. The recombination and expression of KCNK12 protein in laboratory settings allow for detailed studies of its structure-function relationships and interactions with pharmacological agents. This understanding could pave the way for the development of novel treatments aimed at modulating KCNK12 activity in disease contexts. Overall, KCNK12 represents a significant focal point for ongoing research aimed at unraveling the complexities of cellular excitability and its linkage to health and disease.
