Analytical Data
-
Gene name
KCNF1
- Application
-
Alternative Names
KCNF1; Potassium voltage-gated channel subfamily F member 1; Voltage-gated potassium channel subunit Kv5.1; kH1
-
Species
Human
-
Source
E. coli
-
Tag
GST-tag at N-terminal
-
Purity
Greater than 90% as determined by SDS-PAGE.
-
Uniprot
Q9H3M0
-
Expression Region
1-494aa
-
AA Sequence
MDGSGERSLPEPGSQSSAASDDIEIVVNVGGVRQVLYGDLLSQYPETRLAELINCLAGGYDTIFSLCDDYDPGKREFYFDRDPDAFKCVIEVYYFGEVHMKKGICPICFKNEMDFWKVDLKFLDDCCKSHLSEKREELEEIARRVQLILDDLGVDAAEGRWRRCQKCVWKFLEKPESSCPARVVAVLSFLLILVSSVVMCMGTIPELQVLDAEGNRVEHPTLENVETACIGWFTLEYLLRLFSSPNKLHFALSFMNIVDVLAILPFYVSLTLTHLGARMMELTNVQQAVQALRIMRIARIFKLARHSSGLQTLTYALKRSFKELGLLLMYLAVGIFVFSALGYTMEQSHPETLFKSIPQSFWWAIITMTTVGYGDIYPKTTLGKLNAAISFLCGVIAIALPIHPIINNFVRYYNKQRVLETAAKHELELMELNSSSGGEGKTGGSRSDLDNLPPEPAGKEAPSCSSRLKLSHSDTFIPLLTEEKHHRTRLQSCK
-
Molecular Weight
80.08 kDa
-
Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
-
Form
Freeze-dried powder
-
Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
-
Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
-
Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
-
Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
-
Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
Related Products
Protein Description
KCNF1, a member of the potassium channel family, plays a critical role in regulating membrane potential and cellular excitability. Recent studies have highlighted its importance in various physiological processes, including neuronal signaling and cardiac function. Abnormalities in KCNF1 expression or function have been implicated in several diseases, such as epilepsy, cardiac arrhythmias, and other neurological disorders. The recombinant expression of KCNF1 protein is essential for studying its structure-function relationship, elucidating its mechanism of action, and understanding its role in disease. Researchers aim to produce KCNF1 in various expression systems, such as yeast, bacteria, or mammalian cells, to obtain functional and properly folded proteins. Advanced biophysical techniques, including electrophysiology and crystallography, are employed to analyze the ion channel properties and conformational dynamics of KCNF1. Moreover, understanding how KCNF1 interacts with other cellular proteins and signaling pathways is crucial for developing targeted therapeutic strategies. As interest in ion channels as drug targets grows, KCNF1's potential role in pharmacology and its contribution to the pathophysiology of relevante diseases presents an exciting area for ongoing research.
