Analytical Data
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基因名
ARPC4
- Application
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别名
ARPC4；ARC20；Actin-related Protein 2/3 complex subunit 4
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种属
Human
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表达系统
E. coli
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标签
His tag N-Terminus
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
P59998
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表达区间
2-168aa
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氨基酸序列
TATLRPYLS AVRATLQAAL CLENFSSQVV ERHNKPEVEV RSSKELLLQP VTISRNEKEK VLIEGSINSV RVSIAVKQAD EIEKILCHKF MRFMMMRAEN FFILRRKPVE GYDISFLITN FHTEQMYKHK LVDFVIHFME EIDKEISEMK LSVNARARIV AEEFLKNF
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
ARPC4, a crucial component of the Arp2/3 complex, plays a significant role in regulating actin polymerization and cytoskeletal dynamics. Research on ARPC4 has gained momentum due to its involvement in various cellular processes, including cell motility, shape, and intracellular transport, which are essential for normal cell function and development. Dysregulation of actin dynamics associated with ARPC4 has been implicated in several pathological conditions, such as cancer metastasis and neurodegenerative diseases. This has prompted scientists to investigate the structure and function of ARPC4 in detail, using recombinant protein techniques to produce the protein for various biochemical and biophysical assays. Understanding the interactions of ARPC4 with other components of the Arp2/3 complex and its regulatory mechanisms is vital for elucidating its role in cell biology. As a promising target for therapeutic intervention, studies focused on ARPC4 may lead to novel strategies for treating diseases characterized by abnormal actin dynamics. The pursuit of ARPC4 recombinant protein not only enhances our comprehension of the cytoskeletal machinery but also contributes to the broader field of molecular biology, facilitating the development of innovative approaches in the diagnosis and treatment of actin-related disorders.
