Analytical Data
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Gene name
KCNAB1
- Application
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Alternative Names
hKvb3; hKvBeta3; K(+) channel subunit beta-1; KCAB1_HUMAN; KCNA1B; KCNAB1; Kv-beta-1; Kvb1.3; Voltage-gated potassium channel beta-1 subunit; Voltage-gated potassium channel subunit beta-1
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Species
Human
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Source
E. coli
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Tag
His tag N-Terminus
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
Q14722
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Expression Region
1-419aa
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AA Sequence
MLAARTGAAG SQISEENTKL RRQSGFSVAG KDKSPKKASE NAKDSSLSPS GESQLRARQL ALLREVEMNW YLKLCDLSSE HTTVCTTGMP HRNLGKSGLR VSCLGLGTWV TFGGQISDEV AERLMTIAYE SGVNLFDTAE VYAAGKAEVI LGSIIKKKGW RRSSLVITTK LYWGGKAETE RGLSRKHIIE GLKGSLQRLQ LEYVDVVFAN RPDSNTPMEE IVRAMTHVIN QGMAMYWGTS RWSAMEIMEA YSVARQFNMI PPVCEQAEYH LFQREKVEVQ LPELYHKIGV GAMTWSPLAC GIISGKYGNG VPESSRASLK CYQWLKERIV SEEGRKQQNK LKDLSPIAER LGCTLPQLAV AWCLRNEGVS SVLLGSSTPE QLIENLGAIQ VLPKMTSHVV NEIDNILRNK PYSKKDYRS
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Molecular Weight
46.5 kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
KCNAB1, also known as potassium voltage-gated channel subfamily A member 1, is a crucial component of voltage-gated potassium (Kv) channels, which play a significant role in regulating cellular excitability, action potentials, and various physiological functions. Research on KCNAB1 has gained importance due to its involvement in cardiovascular health, neuronal signaling, and potential implications in various pathologies, including arrhythmias and neuropathic pain. Disruptions in KCNAB1 function can lead to significant clinical manifestations, making it a target for therapeutic intervention. The recombinant expression of KCNAB1 allows for the detailed study of its biophysical properties, interactions with other channel subunits, and the effects of specific mutations on channel function. By producing KCNAB1 as a recombinant protein, researchers can employ electrophysiological techniques to elucidate its role in potassium ion conductance and its contribution to channel gating mechanisms. Additionally, understanding the structure-function relationship of KCNAB1 is critical for drug discovery efforts aimed at modulating its activity. Overall, KCNAB1 research serves as a vital avenue for advancing our knowledge of ion channel physiology and developing targeted therapies for ion channel-related disorders.
