Analytical Data
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Gene name
HAS2
- Application
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Alternative Names
HAS2；Hyaluronan synthase 2
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Species
Human
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Source
E. coli
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Tag
His tag N-Terminus
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
Q92819
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Expression Region
1-552aa
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AA Sequence
MHCERFLCILRIIGTTLFGVSLLLGITAAYIVGYQFIQTDNYYFSFGLYGAFLASHLIIQSLFAFLEHRKMKKSLETPIKLNKTVALCIAAYQEDPDYLRKCLQSVKRLTYPGIKVVMVIDGNSEDDLYMMDIFSEVMGRDKSATYIWKNNFHEKGPGETDESHKESSQHVTQLVLSNKSICIMQKWGGKREVMYTAFRALGRSVDYVQVCDSDTMLDPASSVEMVKVLEEDPMVGGVGGDVQILNKYDSWISFLSSVRYWMAFNIERACQSYFGCVQCISGPLGMYRNSLLHEFVEDWYNQEFMGNQCSFGDDRHLTNRVLSLGYATKYTARSKCLTETPIEYLRWLNQQTRWSKSYFREWLYNAMWFHKHHLWMTYEAIITGFFPFFLIATVIQLFYRGKIWNILLFLLTVQLVGLIKSSFASCLRGNIVMVFMSLYSVLYMSSLLPAKMFAIATINKAGWGTSGRKTIVVNFIGLIPVSVWFTILLGGVIFTIYKESKRPFSESKQTVLIVGTLLYACYWVMLLTLYVVLINKCGRRKKGQQYDMVLDV
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Molecular Weight
63.5 kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
Related Products
Protein Description
HAS2, or Hyaluronic Acid Synthase 2, is a vital enzyme responsible for the biosynthesis of hyaluronic acid (HA), a biopolymer that plays a critical role in various physiological processes, including tissue hydration, cell proliferation, and wound healing. Research on HAS2 has gained considerable attention due to its involvement in numerous pathological conditions, such as cancer, inflammation, and cardiovascular diseases. Dysregulation of HA synthesis is linked to tumor progression and metastasis, making HAS2 a potential therapeutic target. The recombinant expression of HAS2 protein allows for detailed biochemical characterizations and provides insights into its enzymatic mechanisms and regulatory pathways. Advances in recombinant DNA technology have enabled researchers to produce HAS2 in microbial or eukaryotic systems, facilitating the study of its functional properties and interactions with other cellular components. Understanding the structural and functional dynamics of HAS2 can pave the way for innovative therapeutic strategies aimed at modulating HA levels in disease contexts, thereby highlighting its significance in both basic and applied biomedical research. The ongoing exploration of HAS2's roles in health and disease underscores its potential as a key player in future pharmaceutical developments.
