Analytical Data
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Gene name
ID2
- Application
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Alternative Names
ID2;BHLHB26;DNA-binding Protein inhibitor ID-2
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Species
Human
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Source
E. coli
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Tag
His tag N-Terminus
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
Q02363
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Expression Region
1-134aa
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AA Sequence
MGSSHHHHHH SSGLVPRGSH MKAFSPVRSV RKNSLSDHSL GISRSKTPVD DPMSLLYNMN DCYSKLKELV PSIPQNKKVS KMEILQHVID YILDLQIALD SHPTIVSLHH QRPGQNQASR TPLTTLNTDI SILSLQASEF PSELMSNDSK ALCG
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Molecular Weight
17 kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
ID2 (Inhibitor of DNA Binding 2) is a member of the helix-loop-helix (HLH) protein family that plays a critical role in cell differentiation, proliferation, and development. Its primary function is to inhibit DNA binding of basic HLH proteins, thereby regulating gene expression involved in various biological processes. Research on ID2 has gained momentum due to its implications in stem cell biology, tumorigenesis, and various developmental disorders. Aberrant expression of ID2 has been linked to several types of cancers, making it a potential biomarker and a target for therapeutic interventions. Recent studies have highlighted the importance of ID2 in maintaining the balance between cell differentiation and self-renewal, particularly in hematopoietic stem cells and neural progenitor cells. Furthermore, ID2's interactions with other proteins and its role in modulating signaling pathways have drawn significant interest from the scientific community, offering insights into its multifaceted functions. Understanding the mechanisms by which ID2 operates at the molecular level could provide valuable information for developing novel strategies in regenerative medicine and cancer therapy. Thus, ongoing investigations into ID2 recombinant proteins aim to elucidate their biological functions and therapeutic potential, making it a key focus in contemporary biomedical research.
