Recombinant Human ID1 Protein，His

ID1, or Inhibitor of DNA Binding 1, is a member of the basic helix-loop-helix (bHLH) transcription factor family, playing a crucial role in regulating cell differentiation, proliferation, and survival. Originally identified for its function as an inhibitor of bHLH proteins, ID1 is implicated in various biological processes, including neovascularization and tumorigenesis. Research has shown that ID1 is often upregulated in numerous cancers, leading to its association with poor prognosis and aggressive tumor behavior. This overexpression is linked to the deregulation of key signaling pathways, including those mediated by growth factors and oncogenes. Moreover, ID1 has emerged as a potential biomarker for cancer diagnosis and prognosis due to its differential expression patterns in various malignancies. Given its significant role in maintaining the undifferentiated state of stem cells and its involvement in epithelial-to-mesenchymal transition (EMT), ID1 offers a promising target for therapeutic interventions. Recent studies are increasingly focusing on unraveling the mechanisms underlying ID1 regulation and function, with the aim of developing novel strategies to inhibit its activity as a means to combat ID1-positive cancers. These investigations highlight the importance of ID1 in both basic biological research and clinical applications, emphasizing the need for further exploration of its pathways and interactions within the cellular environment.