Analytical Data
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基因名
PAIP1
- Application
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别名
PAIP1；Polyadenylate-binding Protein-interacting Protein 1
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种属
Human
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表达系统
E. coli
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标签
His tag N-Terminus
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
Q9H074
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表达区间
1-479aa
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氨基酸序列
MSDGFDRAPGAGRGRSRGLGRGGGGPEGGGFPNGAGPAERARHQPPQPKAPGFLQPPPLRQPRTTPPPGAQCEVPASPQRPSRPGALPEQTRPLRAPPSSQDKIPQQNSESAMAKPQVVVAPVLMSKLSVNAPEFYPSGYSSSYTESYEDGCEDYPTLSEYVQDFLNHLTEQPGSFETEIEQFAETLNGCVTTDDALQELVELIYQQATSIPNFSYMGARLCNYLSHHLTISPQSGNFRQLLLQRCRTEYEVKDQAAKGDEVTRKRFHAFVLFLGELYLNLEIKGTNGQVTRADILQVGLRELLNALFSNPMDDNLICAVKLLKLTGSVLEDAWKEKGKMDMEEIIQRIENVVLDANCSRDVKQMLLKLVELRSSNWGRVHATSTYREATPENDPNYFMNEPTFYTSDGVPFTAADPDYQEKYQELLEREDFFPDYEENGTDLSGAGDPYLDDIDDEMDPEIEEAYEKFCLESERKRKQ
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分子量
61.0 kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
PAIP1 (Polyadenylate Binding Protein Interacting Protein 1) is a critical regulatory protein involved in the control of mRNA translation and stability. Initially discovered for its role in binding to poly(A) tails of mRNAs, PAIP1 facilitates the recruitment of translation initiation factors, thereby enhancing protein synthesis. Beyond its fundamental role in translation, recent studies have highlighted its involvement in various cellular processes, including cell growth, differentiation, and response to stress. Dysregulation of PAIP1 has been associated with several diseases, particularly cancers, where altered protein expression can lead to aberrant mRNA translation and tumor progression. Additionally, PAIP1 has been implicated in processes such as the innate immune response and neuronal function, showcasing its versatile role in different cellular contexts. As a result, the recombinant expression of PAIP1 is of significant interest for further studies aimed at elucidating its molecular mechanisms and potential therapeutic applications. Investigating the structural and functional properties of recombinant PAIP1 can provide valuable insights into its interactions within the cellular milieu, ultimately contributing to the understanding of its role in health and disease.
