Analytical Data
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基因名
IL1F8
- Application
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别名
2310043N20Rik; Family of interleukin 1 eta; FIL1 (ETA); FIL1; FIL1 eta; FIL1H; FILI-(ETA); IL 1F8 (FIL1 eta; IL 1F8; IL 1H2; IL-1 eta; IL-1F8; IL-1H2; IL1 ETA; IL1F8 (Canonical product IL 1F8a); IL1F8; IL1F8_HUMAN; IL1H2; IL36 beta; IL36B; Interleukin 1 family. member 8 (eta); Interleukin 1 family. member 8; Interleukin 1 homolog 2
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种属
Human
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表达系统
E. coli
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标签
His tag N-Terminus
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
Q9NZH7
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表达区间
1-164aa
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氨基酸序列
MNPQREAAPK SYAIRDSRQM VWVLSGNSLI AAPLSRSIKP VTLHLIACRD TEFSDKEKGN MVYLGIKGKD LCLFCAEIQG KPTLQLKLQG SQDNIGKDTC WKLVGIHTCI NLDVRESCFM GTLDQWGIGV GRKKWKSSFQ HHHLRKKDKD FSSMRTNIGM PGRM
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分子量
18.5 kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
Interleukin-1 family member 8 (IL1F8), also known as IL-36 gamma, is a pro-inflammatory cytokine that plays a significant role in the immune response and inflammatory processes. It belongs to a subfamily of interleukins that activate the IL-1 receptor family, influencing various physiological responses, including cell proliferation and differentiation. The interest in IL1F8 has surged due to its potential implications in several inflammatory diseases, such as psoriasis, rheumatoid arthritis, and inflammatory bowel disease. Research has shown that IL1F8 can stimulate the release of other pro-inflammatory cytokines and chemokines, enhancing the local immune response and contributing to chronic inflammation. Understanding the structure and function of IL1F8 is crucial for elucidating its role in disease pathogenesis and therapeutic interventions. The recombinant protein expression of IL1F8 enables detailed studies of its biochemical properties and interactions with specific receptors. Additionally, IL1F8 has emerged as a potential therapeutic target, and thus, insights from recombinant protein research can facilitate the development of new anti-inflammatory treatments, making it a focal point in immunological research.
