Analytical Data
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基因名
IFT57
- Application
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别名
CDNA FLJ10147 fis clone HEMBA1003369; Dermal papilla derived protein 8; Dermal papilla-derived protein 8; DERP 8; DERP8; Esrrbl 1; Esrrbl1; ESRRBL1 protein; Estrogen related receptor beta like 1; Estrogen related receptor beta like protein 1; Estrogen-related receptor beta-like protein 1; FLJ10147; Hip1 Interacting protein; HIP1 interacting protein HIPPI; Hip1 protein interactor; HIP1-interacting protein; HIPPI
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种属
Human
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表达系统
E. coli
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标签
GST-tag at N-terminal
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
Q9NWB7
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表达区间
1-429aa
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氨基酸序列
MTAALAVVTTSGLEDGVPRSRGEGTGEVVLERGPGAAYHMFVVMEDLVEKLKLLRYEEEFLRKSNLKAPSRHYFALPTNPGEQFYMFCTLAAWLINKAGRPFEQPQEYDDPNATISNILSELRSFGRTADFPPSKLKSGYGEHVCYVLDCFAEEALKYIGFTWKRPIYPVEELEEESVAEDDAELTLNKVDEEFVEEETDNEENFIDLNVLKAQTYHLDMNETAKQEDILESTTDAAEWSLEVERVLPQLKVTIRTDNKDWRIHVDQMHQHRSGIESALKETKGFLDKLHNEITRTLEKISSREKYINNQLENLVQEYRAAQAQLSEAKERYQQGNGGVTERTRLLSEVMEELEKVKQEMEEKGSSMTDGAPLVKIKQSLTKLKQETVEMDIRIGIVEHTLLQSKLKEKSNMTRNMHATVIPEPATGFY
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分子量
75.5 kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
IFT57 is a crucial component of the intraflagellar transport (IFT) machinery, which is essential for the assembly and maintenance of cilia and flagella in eukaryotic cells. Cilia are organelles that play vital roles in various biological processes, including cell signaling, motility, and sensory perception. Dysfunction in cilia and their related pathways can lead to a range of diseases, collectively known as ciliopathies, which can affect multiple organ systems, including the kidneys, eyes, and central nervous system. IFT57 is part of the IFT complex, responsible for the bidirectional transport of proteins along the axoneme of cilia. Research on IFT57 has focused on its structural and functional roles within the IFT complex, as well as its interactions with other IFT proteins and cargo molecules. Understanding the mechanisms by which IFT57 operates could provide insights into ciliary assembly and maintenance, potentially leading to therapeutic strategies for ciliopathies. Additionally, studies involving recombinant IFT57 protein facilitate the exploration of its biochemical properties, interactions, and the influence of mutations associated with human diseases. Overall, ongoing research on IFT57 and its role in ciliary dynamics is critical for elucidating the intricate processes governing cilia function and the implications of ciliary dysfunction in human health.
