Analytical Data
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Gene name
CK13
- Application
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Alternative Names
CK13；C11orf13；HRC1；Ras association domain-containing Protein 7
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Species
Human
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Source
E. coli
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Tag
His tag N-Terminus
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
P13646
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Expression Region
1-458aa
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AA Sequence
MSLRLQSSSA SYGGGFGGGS CQLGGGRGVS TCSTRFVSGG SAGGYGGGVS CGFGGGAGSG FGGGYGGGLG GGYGGGLGGG FGGGFAGGFV DFGACDGGLL TGNEKITMQN LNDRLASYLE KVRALEEANA DLEVKIRDWH LKQSPASPER DYSPYYKTIE ELRDKILTAT IENNRVILEI DNARLAADDF RLKYENELAL RQSVEADING LRRVLDELTL SKTDLEMQIE SLNEELAYMK KNHEEEMKEF SNQVVGQVNV EMDATPGIDL TRVLAEMREQ YEAMAERNRR DAEEWFHTKS AELNKEVSTN TAMIQTSKTE ITELRRTLQG LEIELQSQLS MKAGLENTVA ETECRYALQL QQIQGLISSI EAQLSELRSE MECQNQEYKM LLDIKTRLEQ EIATYRSLLE GQDAKMIGFP SSAGSVSPRS TSVTTTSSAS VTTTSNASGR RTSDVRRP
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Molecular Weight
49.5 kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
CK13, or cytokeratin 13, is a type of intermediate filament protein predominantly expressed in the epithelial tissues of the human body. It plays a crucial role in maintaining the structural integrity and functionality of epithelial cells, particularly in the oral cavity, esophagus, and other stratified squamous epithelia. Research into CK13 recombinant proteins has gained significance due to their potential applications in understanding epithelial-related diseases, including cancers and various inflammatory conditions. The ability to produce CK13 as a recombinant protein allows for detailed studies of its biochemical properties, interactions with other cellular proteins, and roles in epithelial homeostasis and pathology. Additionally, CK13 overexpression or dysregulation has been implicated in several malignancies, making it a valuable marker for diagnostic and therapeutic purposes. By utilizing recombinant DNA technology, scientists can generate large quantities of CK13, facilitating advanced research into protein structure-function relationships, cellular signaling pathways, and the development of potential therapeutic interventions targeting CK13 in disease contexts. Overall, the study of CK13 recombinant proteins not only enhances our understanding of epithelial biology but also contributes to the identification of novel biomarkers and therapeutic targets in epithelial-related diseases.
