Analytical Data
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Gene name
HLA-DOB
- Application
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Alternative Names
HLA-DOB;HLA class II histocompatibility antigen. DO beta chain
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Species
Human
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Source
E. coli
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Tag
His tag N-Terminus
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
P13765
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Expression Region
27-224aa
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AA Sequence
MGSSHHHHHH SSGLVPRGSH MGSGTDSPED FVIQAKADCY FTNGTEKVQF VVRFIFNLEE YVRFDSDVGM FVALTKLGQP DAEQWNSRLD LLERSRQAVD GVCRHNYRLG APFTVGRKVQ PEVTVYPERT PLLHQHNLLH CSVTGFYPGD IKIKWFLNGQ EERAGVMSTG PIRNGDWTFQ TVVMLEMTPE LGHVYTCLVD HSSLLSPVSV EWRAQSEYSW RK
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Molecular Weight
25 kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
Related Products
Protein Description
HLA-DOB (Human Leukocyte Antigen - DOB) is a crucial component of the major histocompatibility complex (MHC) class II molecules, playing a significant role in the immune response. It functions as a partner for HLA-DM, facilitating the proper loading of peptide fragments into MHC class II molecules, which are essential for T-cell activation and subsequent adaptive immunity. Research into HLA-DOB has gained traction due to its implications in various autoimmune diseases, infectious diseases, and transplant immunology. Understanding the structural and functional properties of HLA-DOB is vital for elucidating its role in antigen presentation and immune regulation. Furthermore, the study of HLA-DOB has potential therapeutic applications, as it can serve as a target for vaccine development or immunotherapy approaches aimed at modulating the immune system. Moreover, exploring HLA-DOB's association with specific human leukocyte antigen (HLA) haplotypes may provide insights into genetic predispositions to certain diseases, enhancing our understanding of population genetics and disease susceptibility. Overall, the investigation of HLA-DOB recombinant protein is of paramount importance for advancing our knowledge of immune mechanisms and developing innovative strategies for treating immune-related conditions.
