Analytical Data
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Gene name
IFIT1
- Application
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Alternative Names
IFIT-1;Interferon-induced 56 kDa protein;IFI-56K;P56
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Species
Human
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Source
E. coli
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Tag
GST-tag at N-terminal
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
P09914
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Expression Region
1-478aa
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AA Sequence
MSTNGDDHQVKDSLEQLRCHFTWELSIDDDEMPDLENRVLDQIEFLDTKYSVGIHNLLAYVKHLKGQNEEALKSLKEAENLMQEEHDNQANVRSLVTWGNFAWMYYHMGRLAEAQTYLDKVENICKKLSNPFRYRMECPEIDCEEGWALLKCGGKNYERAKACFEKVLEVDPENPESSAGYAISAYRLDGFKLATKNHKPFSLLPLRQAVRLNPDNGYIKVLLALKLQDEGQEAEGEKYIEEALANMSSQTYVFRYAAKFYRRKGSVDKALELLKKALQETPTSVLLHHQIGLCYKAQMIQIKEATKGQPRGQNREKLDKMIRSAIFHFESAVEKKPTFEVAHLDLARMYIEAGNHRKAEENFQKLLCMKPVVEETMQDIHFHYGRFQEFQKKSDVNAIIHYLKAIKIEQASLTRDKSINSLKKLVLRKLRRKALDLESLSLLGFVYKLEGNMNEALEYYERALRLAADFENSVRQGP
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Molecular Weight
62.3 kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
IFIT1 (Interferon-Inducible Protein 1) is a member of the interferon-stimulated gene family, playing a critical role in the innate immune response. It is primarily expressed upon viral infection and acts as a key regulator in the host's defense mechanism against pathogens. Research has shown that IFIT1 is involved in recognizing and binding to viral RNA, thus facilitating the degradation of viral genomes and inhibiting viral replication. The protein has been linked to various antiviral activities, including the modulation of signaling pathways that lead to enhanced expression of other antiviral proteins. Additionally, IFIT1 interacts with various cellular factors, suggesting its involvement in broader regulatory networks within the immune system. The study of IFIT1 recombinant proteins has garnered attention due to their potential therapeutic applications in infectious diseases and cancer. By providing clearer insights into the molecular mechanisms of IFIT1, researchers aim to develop novel strategies for bolstering immune responses or designing antiviral drugs. Understanding the structure-function relationship of IFIT1 through recombinant protein studies could pave the way for innovative treatments and a better understanding of immune regulation. Overall, the exploration of IFIT1 and its recombinant forms not only advances our fundamental knowledge of host-pathogen interactions but also holds promise for the development of targeted immunotherapies.
