Analytical Data
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Gene name
GABRP
- Application
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Alternative Names
GABRP；Gamma-aminobutyric acid receptor subunit pi
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Species
Human
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Source
E. coli
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Tag
His tag N-Terminus
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
O00591
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Expression Region
17-242aa
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AA Sequence
ERMCIQGSQFNVEVGRSDKLSLPGFENLTAGYNKFLRPNFGGEPVQIALTLDIASISSISESNMDYTATIYLRQRWMDQRLVFEGNKSFTLDARLVEFLWVPDTYIVESKKSFLHEVTVGNRLIRLFSNGTVLYALRITTTVACNMDLSKYPMDTQTCKLQLESWGYDGNDVEFTWLRGNDSVRGLEHLRLAQYTIERYFTLVTRSQQETGNYTRLVLQFELRRNV
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Molecular Weight
28.9 kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
The GABRP (Gamma-Aminobutyric Acid Receptor Associated Protein) is an important component of the GABAergic system, which plays a crucial role in inhibitory neurotransmission in the central nervous system. Research on GABRP has gained momentum due to its potential implications in various neurological and psychiatric disorders, including anxiety, epilepsy, and schizophrenia. GABRP is known to modulate the function of GABAA receptors, which are the primary mediators of inhibitory signaling in the brain. Understanding GABRP's structure and function can provide insights into its role in neural circuit dynamics and how disruptions in this system may contribute to various pathologies. Recent advancements in recombinant protein technology have enabled the production and characterization of GABRP, facilitating studies to uncover its physiological roles and interactions with other proteins. This research is vital for developing new therapeutic strategies targeting GABRP or related pathways, potentially leading to novel treatments for conditions that stem from GABAergic dysfunction. The ongoing investigation into GABRP and its functionalities is thus crucial for advancing our understanding of the brain's complex signaling networks and their relevance to mental health.
