Analytical Data
-
Gene name
HOXD8
- Application
-
Alternative Names
homeo box 4E; homeo box D8; Homeobox 4E; homeobox D8; homeobox protein 5.4; Homeobox protein Hox-4E; Homeobox protein Hox-5.4; Homeobox protein Hox-D8; Hox-4.5; Hox-4.5. mouse. homolog of; Hox-4E; Hox-5.4 ; HOX4; HOX4E; Hoxd8; HXD8_HUMAN
-
Species
Human
-
Source
E. coli
-
Tag
GST-tag at N-terminal
-
Purity
Greater than 90% as determined by SDS-PAGE.
-
Uniprot
P13378
-
Expression Region
1-289aa
-
AA Sequence
MSSYFVNPLYSKYKAAAAAAAAAGEAINPTYYDCHFAPGVGGRHAAAAAALQLYGNSAAGFPHAPPQAHAHPHPSPPPSGTGCGGREGRGQEYFHPGGGSPAAAYQAAPPPPPHPPPPPPPPPCGGIACHGEPAKFYGYDNLQRQPIFTTQQEAELVQYPDCKSSSGNIGEDPDHLNQSSSPSQMFPWMRPQAPGRRRGRQTYSRFQTLELEKEFLFNPYLTRKRRIEVSHALALTERQVKIWFQNRRMKWKKENNKDKFPVSRQEVKDGETKKEAQELEEDRAEGLTN
-
Molecular Weight
58.2 kDa
-
Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
-
Form
Freeze-dried powder
-
Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
-
Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
-
Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
-
Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
-
Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
Related Products
Protein Description
HOXD8, a member of the homeobox gene family, plays a crucial role in the regulation of embryonic development and patterning. Research has shown that HOXD8 is essential for the formation of limbs and the axial skeleton during early stages of development. Its expression is tightly regulated and localized, suggesting its involvement in mechanisms that determine cell fate and tissue differentiation. In recent years, the focus on HOXD8 has expanded beyond developmental biology to include its potential implications in various diseases, such as cancer, where aberrant expression can influence tumor progression and metastasis. The production of recombinant HOXD8 protein facilitates in-depth studies of its functional properties and interactions at the molecular level. Using techniques such as protein expression and purification, researchers aim to elucidate the biochemical pathways influenced by HOXD8, and its role as a transcription factor in cellular processes. Additionally, understanding its interactions with other proteins may reveal insights into its regulatory networks and the consequences of its dysregulation. The ongoing investigation of HOXD8 as a recombinant protein not only enhances our fundamental understanding of developmental processes but also opens potential avenues for therapeutic interventions targeting HOXD8-related pathways in diseases. Overall, the study of HOXD8 represents a significant intersection of developmental biology, molecular genetics, and disease pathology, making it a prominent focus of current scientific inquiry.
