Analytical Data
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Gene name
HOXD1
- Application
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Alternative Names
homeo box 4G; homeo box D1; Homeobox protein Hox D1; Homeobox protein Hox-D1; Homeobox protein Hox-GG; HOX 4; HOX 4G; HOX D1; Hox-4.7; HOX4; Hox4.9; HOX4G; hoxd1; HXD1_HUMAN; OTTHUMP00000163336
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Species
Human
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Source
E. coli
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Tag
GST-tag at N-terminal
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
Q9GZZ0
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Expression Region
1-328aa
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AA Sequence
MSSYLEYVSCSSSGGVGGDVLSLAPKFCRSDARPVALQPAFPLGNGDGAFVSCLPLAAARPSPSPPAAPARPSVPPPAAPQYAQCTLEGAYEPGAAPAAAAGGADYGFLGSGPAYDFPGVLGRAADDGGSHVHYATSAVFSGGGSFLLSGQVDYAAFGEPGPFSACLKASADGHPGAFQTASPAPGTYPKSVSPASGLPAAFSTFEWMKVKRNASKKGKLAEYGAASPSSAIRTNFSTKQLTELEKEFHFNKYLTRARRIEIANCLHLNDTQVKIWFQNRRMKQKKREREGLLATAIPVAPLQLPLSGTTPTKFIKNPGSPSQSQEPS
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Molecular Weight
60.5 kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
HOXD1, a member of the homeobox gene family, plays a crucial role in embryonic development and patterning of the vertebrate limb and axial skeleton. Research has shown that HOXD1 is involved in regulating gene expression during developmental processes, particularly in the establishment of the anteroposterior axis and limb bud formation. Its misregulation has been linked to congenital malformations and various disorders, making it a significant target for understanding developmental biology and evolutionary processes. The recombinant protein of HOXD1 is being studied to elucidate its functional mechanisms and interactions with other proteins involved in developmental pathways. Through the production of HOXD1 as a recombinant protein, researchers aim to investigate its structural properties and biological activity, shedding light on its role in gene regulation and potential implications in regenerative medicine and gene therapy. Understanding HOXD1's function at a molecular level is necessary for developing therapeutic strategies for diseases associated with its dysfunction. Moreover, the study of HOXD1 can provide insights into the evolutionary conservation of developmental mechanisms across species, further highlighting its importance in both developmental biology and genetic research.
