Analytical Data
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基因名
HOXA11
- Application
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别名
Homeo box 1I; Homeo box A11 ; Homeobox A11; Homeobox protein Hox A11; Homeobox protein Hox-1I; Homeobox protein Hox-A11; Homeobox protein HOXA11; Hox 1I; HOX1; HOX1I ; HOXA11; HXA11_HUMAN
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种属
Human
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表达系统
E. coli
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标签
GST-tag at N-terminal
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
P31270
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表达区间
1-313aa
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氨基酸序列
MDFDERGPCSSNMYLPSCTYYVSGPDFSSLPSFLPQTPSSRPMTYSYSSNLPQVQPVREVTFREYAIEPATKWHPRGNLAHCYSAEELVHRDCLQAPSAAGVPGDVLAKSSANVYHHPTPAVSSNFYSTVGRNGVLPQAFDQFFETAYGTPENLASSDYPGDKSAEKGPPAATATSAAAAAAATGAPATSSSDSGGGGGCRETAAAAEEKERRRRPESSSSPESSSGHTEDKAGGSSGQRTRKKRCPYTKYQIRELEREFFFSVYINKEKRLQLSRMLNLTDRQVKIWFQNRRMKEKKINRDRLQYYSANPLL
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分子量
60.9 kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
HOXA11 is a member of the Homeobox gene family, which plays a crucial role in regulating developmental processes and cell differentiation. Its expression is particularly significant in the context of limb development, organ formation, and reproductive biology. Studies have shown that HOXA11 is involved in the regulation of gene expression during embryonic development, influencing the formation of structures such as the digits and the reproductive tract. Abnormal expression or mutation of HOXA11 has been linked to various developmental disorders and diseases, including congenital limb malformations and certain types of cancer. As researchers seek to understand the underlying mechanisms of these conditions, the production and characterization of recombinant HOXA11 protein have become essential. This allows scientists to explore the functional properties of HOXA11, including its DNA-binding capabilities and its interactions with other regulatory proteins. Such studies can elucidate the role of HOXA11 in transcriptional regulation and its implications in both normal development and disease states. By utilizing recombinant protein techniques, researchers aim to develop therapeutic strategies that can potentially correct the dysregulation of HOXA11 function, opening new avenues for treating related disorders. Overall, the investigation of recombinant HOXA11 not only enhances our understanding of developmental biology but also contributes to the advancement of targeted therapeutic approaches in regenerative medicine and oncology.
