Analytical Data
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基因名
HORMAD2
- Application
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别名
4930529M09Rik; CT46.2; HORM2_HUMAN; HORMA domain containing 2; HORMA domain-containing protein 2; Hormad2; MGC26710; RP23-329P17.4
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种属
Human
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表达系统
E. coli
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标签
GST-tag at N-terminal
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
Q8N7B1
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表达区间
1-307aa
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氨基酸序列
MATAQLSHCITIHKASKETVFPSQITNEHESLKMVKKLFATSISCITYLRGLFPESSYGERHLDDLSLKILREDKKCPGSLHIIRWIQGCFDALEKRYLRMAVLTLYTDPMGSEKVTEMYQFKFKYTKEGATMDFDSHSSSTSFESGTNNEDIKKASVLLIRKLYILMQDLEPLPNNVVLTMKLHYYNAVTPHDYQPLGFKEGVNSHFLLFDKEPINVQVGFVSTGFHSMKVKVMTEATKVIDLENNLFRENSTTEIAHQGLDCDEEEECNDHIQRMNFVCSQQSSECSRKKRKVSEPVKVFIPNRK
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分子量
61.7 kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
HORMAD2, or Hormone-Related Protein 2, is a critical player in the process of meiosis, particularly in the context of homologous recombination and the formation of synaptonemal complexes. This protein is primarily expressed in germ cells and is essential for the proper alignment and pairing of homologous chromosomes during meiosis, which is vital for successful gametogenesis. Abnormal expression or function of HORMAD2 can lead to issues such as infertility, aneuploidy, and various reproductive disorders. Recent studies have shown that HORMAD2 interacts with other key proteins involved in meiotic processes, highlighting its role in facilitating the double-strand break repair mechanisms necessary for genetic diversity. Moreover, understanding the structure and function of HORMAD2, particularly through the study of its recombinant protein, could provide insights into the molecular underpinnings of fertility and the potential for developing targeted therapeutic strategies for reproductive health issues. The recombinant expression of HORMAD2 allows researchers to investigate its biochemical properties and interactions in a controlled environment, further unraveling its contribution to the complex network of meiotic regulation. Given the importance of preserving genomic integrity during meiosis, the study of HORMAD2 and its associated pathways remains a significant area of research with promising implications for both basic biology and clinical applications.
