Cat: PA1000-1323

Recombinant Human GPX1 Protein,His

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Analytical Data

  • 基因名

    GPX1

  • Application

    SPRMSTBLIITCELISA细胞实验药物筛选

  • 别名

    GPX1;Glutathione peroxidase 1

  • 种属

    Human

  • 表达系统

    E. coli

  • 标签

    His tag N-Terminus

  • 纯度

    Greater than 90% as determined by SDS-PAGE.

  • 蛋白编号

    P07203

  • 表达区间

    1-203aa

  • 氨基酸序列

    MGSSHHHHHHSSGLVPRGSHMCAARLAAAAAAAQSVYAFSARPLAGGEPV SLGSLRGKVLLIENVASLCGTTVRDYTQMNELQRRLGPRGLVVLGFPCNQ FGHQENAKNEEILNSLKYVRPGGGFEPNFMLFEKCEVNGAGAHPLFAFLR EALPAPSDDATALMTDPKLITWSPVCRNDVAWNFEKFLVGPDGVPLRRYS RRFQTIDIEPDIEALLSQGPSCA

  • 分子量

    24 kDa

  • 内毒素

    < 1.0 EU per μg protein as determined by the LAL method.

  • 性状

    Freeze-dried powder

  • 缓冲液

    PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.

  • 复溶方法

    Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.

  • 个性化定制

    点位突变 标签定制 buffer定制 全长蛋白定制

  • 稳定性测试

    The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.

  • 保存条件 & 期限

    Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.

  • 运输条件

    In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.

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Protein Description

GPX1, or Glutathione Peroxidase 1, is an essential antioxidant enzyme that plays a crucial role in cellular defense against oxidative stress. It catalyzes the reduction of hydrogen peroxide and hydroperoxides using glutathione, thereby maintaining redox homeostasis and protecting cells from oxidative damage. Research has identified GPX1 as a significant factor in various physiological processes, including inflammation, aging, and the progression of numerous diseases, such as cancer and neurodegenerative disorders. Genetic variations in the GPX1 gene can influence enzyme activity and have been associated with altered disease susceptibility and outcomes. Due to its importance, GPX1 has emerged as a target for therapeutic interventions aimed at enhancing antioxidant defenses. The study of recombinant GPX1 proteins is pivotal for understanding its functional mechanisms, potential regulatory pathways, and interactions with other cellular components. By producing GPX1 in a recombinant form, researchers can investigate the enzyme's biochemical properties, assess the impacts of specific mutations, and evaluate the potential for developing GPX1-based treatments. Additionally, recombinant GPX1 can serve as a valuable tool in pharmaceutical applications and for the development of diagnostic assays aimed at assessing oxidative stress in various health conditions. Thus, ongoing research into GPX1 and its recombinant forms holds promise for advancing our understanding of oxidative stress-related diseases and improving therapeutic strategies.

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IPODIX North America (HQ)
Proteintech Group, Inc
5500 Pearl Street, Suite 400
Rosemont, IL 60018, USA
1-888-478-4522
proteintech@ptglab.com
IPODIX North America (HQ)
Proteintech Group, Inc
5500 Pearl Street, Suite 400
Rosemont, IL 60018, USA
1-888-478-4522
proteintech@ptglab.com
IPODIX North America (HQ)
Proteintech Group, Inc
5500 Pearl Street, Suite 400
Rosemont, IL 60018, USA
1-888-478-4522
proteintech@ptglab.com
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