Analytical Data
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Gene name
HMX1
- Application
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Alternative Names
HMX1; H6; Homeobox protein HMX1; Homeobox protein H6
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Species
Human
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Source
E. coli
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Tag
GST-tag at N-terminal
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
Q9NP08
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Expression Region
1-348aa
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AA Sequence
MPDELTEPGRATPARASSFLIENLLAAEAKGAGRATQGDGSREDEEEDDDDPEDEDAEQARRRRLQRRRQLLAGTGPGGEARARALLGPGALGLGPRPPPGPGPPFALGCGGAARWYPRAHGGYGGGLSPDTSDRDSPETGEEMGRAEGAWPRGPGPGAVQREAAELAARGPAAGTEEASELAEVPAAAGETRGGVGVGGGRKKKTRTVFSRSQVFQLESTFDLKRYLSSAERAGLAASLQLTETQVKIWFQNRRNKWKRQLAAELEAASLSPPGAQRLVRVPVLYHESPPAAAAAGPPATLPFPLAPAAPAPPPPLLGFSGALAYPLAAFPAAASVPFLRAQMPGLV
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Molecular Weight
64.68 kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
Related Products
Protein Description
HMX1, or Hemojuvelin, is a protein that plays a crucial role in iron homeostasis and regulation within the human body. As a member of the bone morphogenic protein (BMP) family, HMX1 is primarily involved in the regulation of hepcidin, a key hormone in iron metabolism. Dysfunction in HMX1 has been associated with various iron-related disorders, including hereditary hemochromatosis and iron-refractory iron deficiency anemia. Recent research has focused on the recombinant expression of HMX1, aiming to better understand its structure and function, as well as its interactions with other proteins involved in iron regulation. The production of recombinant HMX1 allows for detailed biochemical studies, providing insights into its molecular mechanisms and potential therapeutic applications. Furthermore, understanding HMX1's role may lead to novel strategies for treating iron overload conditions and improving erythropoiesis in patients with anemia. Thus, the study of HMX1 recombinant protein is a vital area of research, bridging basic science and potential clinical interventions in hematology and metabolic disorders.
