Analytical Data
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基因名
GNG12
- Application
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别名
GNG12;Guanine nucleotide-binding Protein G(I)/G(S)/G(O) subunit gamma-12
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种属
Human
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表达系统
E. coli
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标签
His tag N-Terminus
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
Q9UBI6
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表达区间
1-69aa
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氨基酸序列
MGSSHHHHHHSSGLVPRGSHMGSMSSKTASTNNIAQARRTVQQLRLEASI ERIKVSKASADLMSYCEEHARSDPLLIGIPTSENPFKDKKTC
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分子量
10 kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
GNG12 (Guanine nucleotide-binding protein G (i) subunit gamma-12) is a member of the G-protein gamma subunit family, which plays a crucial role in the signaling pathways mediated by G-protein-coupled receptors (GPCRs). These receptors are vital for numerous physiological processes, including sensory perception, immune response, and cell communication. The GNG12 subunit is involved in the formation of G-protein complexes that transmit signals from extracellular stimuli to intracellular effector pathways. Recent studies have highlighted the significance of GNG12 in various diseases, including cancer and neurological disorders, where dysregulation of GPCR signaling can lead to aberrant cellular functions. As a result, the investigation of GNG12 as a potential therapeutic target has gained momentum. To facilitate this research, the production of recombinant GNG12 protein is critical for biochemical assays and structural studies. Understanding the molecular mechanisms by which GNG12 interacts with other G-protein subunits and receptors will provide insights into its functional roles and may lead to the development of new therapeutic strategies. Through advanced biotechnological methods, including gene cloning and expression systems, researchers are now able to obtain high-purity recombinant GNG12, paving the way for comprehensive studies on its structure and function in cellular signaling.
